{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:26Z","timestamp":1791942446240,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R150\u2010A10023"],"award-info":[{"award-number":["R150\u2010A10023"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with multiple myeloma (MM) may be particularly vulnerable to depression and anxiety following diagnosis due to high disease burden, treatment\u2010related side effects, and the incurable nature of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide population\u2010based cohort study, we used Danish population\u2010based registries to investigate the risk of depression and anxiety in patients with MM (symptomatic MM and smoldering MM) compared with age\u2010 and sex\u2010matched individuals from the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3861 patients with MM and 19\u2009305 matched comparators were included (median age 73\u2009years; 59% male). During follow\u2010up, depression and\/or anxiety occurred in 315\u2009MM patients (8.2%) and 660 comparators (3.4%). MM was associated with a substantially increased risk of depression and\/or anxiety (adjusted HR 2.56, 95% CI 2.23\u20132.94). The association was strongest among patients with symptomatic MM (adjusted HR 2.63, 95% CI 2.21\u20133.12) but remained elevated among patients with smoldering MM (adjusted HR 1.44, 95% CI 1.10\u20131.87). The association was strongest during the first year following diagnosis and attenuated over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate an elevated risk of depression and\/or anxiety among patients with both symptomatic and smoldering MM and highlight the need for increased awareness of psychological morbidity, particularly during the first year after diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70339","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:25:30Z","timestamp":1791941130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Risks for Depression and Anxiety Following Diagnosis of Multiple Myeloma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4705-2866","authenticated-orcid":false,"given":"Klara F. K.","family":"Rydahl","sequence":"first","affiliation":[{"name":"Quality of Life Research Center, Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Affective Disorders Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Kiesbye","family":"\u00d8vlisen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-9198","authenticated-orcid":false,"given":"Trine Allerslev","family":"Horsb\u00f8l","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-4269","authenticated-orcid":false,"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology, Biostatistics, and Biodemography University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-3870","authenticated-orcid":false,"given":"Lene Kongsgaard","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Quality of Life Research Center, Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Hematology G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-6208","authenticated-orcid":false,"given":"S\u00f8ren Dinesen","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-506X","authenticated-orcid":false,"given":"Christopher","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.101155","article-title":"Anxiety and Depression in Adult Cancer Patients: ESMO Clinical Practice Guideline","volume":"8","author":"Grassi L.","year":"2023","journal-title":"ESMO Open"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of Depression, Anxiety, and Adjustment Disorder in Oncological, Haematological, and Palliative\u2010Care Settings: A Meta\u2010Analysis of 94 Interview\u2010Based Studies","volume":"12","author":"Mitchell A. 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