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Here we present the effects of unilateral 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> lesions to either the medial forebrain bundle or the substantia nigra (<jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>) in mice, which were trained on a lateralised choice reaction time (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) task. This task measures response accuracy as well as <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and movement time latencies, and offers the opportunity for a more fine\u2010grained analysis of the precise nature of the movement deficit, motor learning and functional recovery than can be achieved using classical tests of simple motor asymmetry. Both lesion types caused impaired response accuracy, which was more pronounced when responses had to be directed contralateral to the lesion. Furthermore, movement times were increased for both lesion groups, whereas only the bundle lesion group displayed a <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> deficit. The lesions were stable over three consecutive weeks of testing, therefore lesion\u2010type and behavioural assessment on the operant task are suitable to investigate the dopaminergic system in parkinsonian mice. Both lesions were stable over time, and were more pronounced when responses were directed in contralateral space; the mice with more complete bundle lesions displayed a greater deficit than mice that received lesions to the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>. The translation of this choice <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> task will be beneficial for the assessment of therapeutics in mouse models of the disease.<\/jats:p>","DOI":"10.1111\/ejn.12036","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T04:31:19Z","timestamp":1351744279000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of 6\u2010hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Andreas","family":"Heuer","sequence":"first","affiliation":[{"name":"Brain Repair Group School of Bioscience Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaynor A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Brain Repair Group School of Bioscience Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[{"name":"Brain Repair Group School of Bioscience Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.10.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2131"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08491.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00067-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05285.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.371"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.3.484"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00044-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.5.987"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1523\/JNEUROSCI.09-03-00983.1989","article-title":"Deficits in response space following unilateral striatal dopamine depletion in rats","volume":"9","author":"Brown V.J.","year":"1989","journal-title":"J. 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