{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:56:31Z","timestamp":1791309391512,"version":"4.3.1"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noninvasive neurostimulation techniques have been used alone or in conjunction with rehabilitation therapy to treat the neurological sequelae of brain damage with rather variable therapeutic outcomes. One potential factor limiting a consistent success for such techniques may be the limited number of sessions carried out in patients, despite reports that their accrual may play a key role in alleviating neurological deficits long\u2010term. In this study, we tested the effects of seventy consecutive sessions of perilesional high\u2010frequency (10\u00a0Hz) repetitive transcranial magnetic stimulation (<jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>) in the treatment of chronic neglect deficits in a well\u2010established feline model of visuospatial neglect. Under identical <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content> parameters and visuospatial testing regimes, half of the subjects improved in visuospatial orienting performance. The other half experienced either none or extremely moderate ameliorations in the neglected hemispace and displayed transient patterns of maladaptive visuospatial behavior. Detailed analyses suggest that lesion location and extent did not account for the behavioral differences observed between these two groups of animals. We conclude that multi\u2010session perilesional <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content> regimes have the potential to induce functional ameliorations following focal chronic brain injury, and that behavioral performance prior to the onset of the <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content> treatment is the factor that best predicts positive outcomes for noninvasive neurostimulation treatments in visuospatial neglect.<\/jats:p>","DOI":"10.1111\/ejn.12055","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T11:12:37Z","timestamp":1353496357000},"page":"441-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Benefit of multiple sessions of perilesional repetitive transcranial magnetic stimulation for an effective rehabilitation of visuospatial function"],"prefix":"10.1111","volume":"37","author":[{"given":"Linda","family":"Afifi","sequence":"first","affiliation":[{"name":"Laboratory of Cerebral Dynamics, Plasticity and Rehabilitation Department of Anatomy and Neurobiology Boston University School of Medicine Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jarrett Rushmore","sequence":"additional","affiliation":[{"name":"Laboratory of Cerebral Dynamics, Plasticity and Rehabilitation Department of Anatomy and Neurobiology Boston University School of Medicine Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Valero\u2010Cabr\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Cerebral Dynamics, Plasticity and Rehabilitation Department of Anatomy and Neurobiology Boston University School of Medicine Boston USA"},{"name":"Equipe de Dinamiques C\u00e9r\u00e9brales, Plasticit\u00e9 et R\u00e9education CNRS 7225\u2010CRICM &amp; CNRS UMR 5105\u2010LPNC and TREAT vision Fondation Ophtalmologique Rothschild Paris France"},{"name":"Berenson\u2010Allen Center for Non\u2010invasive Brain Stimulation Beth Israel Deaconess Medical Center and Department of Neurology Harvard Medical School Boston MA USA"},{"name":"Cognitive Neuroscience and Information Technology Research Program Open University of Catalonia (UOC) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/81453"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(90)90061-H"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182436558"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108464"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00310-0"},{"key":"e_1_2_8_7_1","first-page":"123","article-title":"Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients","volume":"25","author":"Boggio P.","year":"2007","journal-title":"Restor. Neurol. Neurosci."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf081"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01283-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21393"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0316-12.2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080184"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000177010.44602.5e"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01013.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00109-8"},{"key":"e_1_2_8_16_1","first-page":"9","article-title":"Combined transcranial direct current stimulation and robot\u2010assisted arm training in subacute stroke patients: a pilot study","volume":"25","author":"Hesse S.","year":"2007","journal-title":"Restor. Neurol. Neurosci."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh369"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000108)429:2<221::AID-CNE4>3.0.CO;2-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21658"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.11.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000173067.84247.36"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221233.55497.51"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823ed08f"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)57010-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1216-x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000432"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00008-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161839.38079.92"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200110290-00039"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050153"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00027-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.10.004"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2011.04.004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.7.1338"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901770205"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144216"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.540823"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000034149.72481.BD"},{"key":"e_1_2_8_40_1","volume-title":"Topographischer Hirnatlas der Katze, fur Experimental\u2010Physiologische Untersuchungen","author":"Reinoso\u2010Suarez F.","year":"1961"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805413106"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.016"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00485-X"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.6.814"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl140"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2278-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1245-0"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(77)90146-1"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1027-7"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/16501970500441807"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5316-03.2004"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05440.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05682.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp154"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112070"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189658.51972.34"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0181"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.10.014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1109\/MEMB.2005.1384097"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-004-2140-6"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0307-4"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0639-8"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06045.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.9.061206.133100"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10686"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.522144"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00903-0"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.12055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.12055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:19:40Z","timestamp":1700612380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.12055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/ejn.12055"],"URL":"https:\/\/doi.org\/10.1111\/ejn.12055","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]},"assertion":[{"value":"2012-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}