{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:36:48Z","timestamp":1767991008114,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neurotransmitter dopamine (<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) plays a critical role in both priming\u2010and cue\u2010induced reinstatement of extinguished drug\u2010seeking behavior, but its role in stress\u2010induced reinstatement is less clear. Our laboratory has recently demonstrated that systemic administration of the <jats:styled-content style=\"fixed-case\">DA D<\/jats:styled-content>1\u2010like receptor antagonist, <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> 23390, attenuates acute food deprivation (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) stress\u2010induced reinstatement. The current study was designed to elucidate the brain regions critical to the effect of <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> 23390 on <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> stress\u2010induced reinstatement. Rats were trained to press a lever to self\u2010administer heroin (0.1\u00a0mg\/kg\/inf) over a period of 10\u00a0days. Following training, heroin was removed leading to an extinction of lever pressing. Next, rats were tested for reinstatement twice, under extinction conditions: once following 21\u201348\u00a0h <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>; and once under sated conditions. Prior to testing, <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> 23390 was administered into the nucleus accumbens (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c) shell (0.0, 0.3, 0.6\u00a0\u03bcg\/side), <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c core (0.0, 0.3, 0.6\u00a0\u03bcg\/side), dorsomedial prefrontal cortex (dm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>; 0.0, 0.2, 2.0\u00a0\u03bcg\/side), ventromedial prefrontal cortex (vm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>; 0.0, 2.0\u00a0\u03bcg\/side) or basolateral amygdala (<jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>; 0.0, 1.0, 2.0\u00a0\u03bcg\/side). An attenuation of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010induced reinstatement of heroin seeking was seen in rats injected with <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> 23390 into the <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c shell, dm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>, but not into the <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c core or the vm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>. These findings support the hypothesis that <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> transmission through the <jats:styled-content style=\"fixed-case\">DA D<\/jats:styled-content>1\u2010like receptors plays a critical role in stress\u2010induced reinstatement of heroin seeking.<\/jats:p>","DOI":"10.1111\/ejn.12112","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T10:38:10Z","timestamp":1358332690000},"page":"972-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Antagonism of the dopamine <scp>D<\/scp>1\u2010like receptor in mesocorticolimbic nuclei attenuates acute food deprivation\u2010induced reinstatement of heroin seeking in rats"],"prefix":"10.1111","volume":"37","author":[{"given":"Stephanie","family":"Tobin","sequence":"first","affiliation":[{"name":"Department of Psychology Center for Studies in Behavioral Neurobiology\/Groupe de Recherche 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