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Although decreased DA<\/jats:styled-content> D2\/D3 receptor availability in the nucleus accumbens (NA<\/jats:styled-content>cb) predicts trait\u2010like impulsivity in rats it is unclear whether this neurochemical marker extends to both the NA<\/jats:styled-content>cb core (NA<\/jats:styled-content>cbC) and shell (NA<\/jats:styled-content>cbS) and whether markers for other neurotransmitter systems implicated in impulsivity such as serotonin (5\u2010HT<\/jats:styled-content>), endogenous opioids and \u03b3\u2010amino\u2010butyric acid (GABA<\/jats:styled-content>) are likewise altered in impulsive rats. We therefore used autoradiography to investigate DA<\/jats:styled-content> transporter (DAT<\/jats:styled-content>), 5\u2010HT<\/jats:styled-content> transporter (5\u2010HTT<\/jats:styled-content>) and D<\/jats:styled-content>1, D<\/jats:styled-content>2\/D<\/jats:styled-content>3, \u03bc\u2010opioid and GABA<\/jats:styled-content>(A) receptor binding in selected regions of the prefrontal cortex and striatum in rats expressing low and high impulsive behaviour on the five\u2010choice serial reaction\u2010time task. High\u2010impulsive (HI<\/jats:styled-content>) rats exhibited significantly lower binding for DAT<\/jats:styled-content> and D<\/jats:styled-content>2\/D<\/jats:styled-content>3 receptors in the NA<\/jats:styled-content>cbS and for D<\/jats:styled-content>1 receptors in the NA<\/jats:styled-content>cbC compared with low\u2010impulsive (LI<\/jats:styled-content>) rats. HI<\/jats:styled-content> rats also showed significantly lower GABA<\/jats:styled-content>(A) receptor binding in the anterior cingulate cortex. For all regions where receptor binding was altered in HI<\/jats:styled-content> rats, binding was inversely correlated with impulsive responding on task. There were no significant differences in binding for 5\u2010HTT<\/jats:styled-content> or \u03bc\u2010opioid receptors in any of the regions investigated. These results indicate that altered D<\/jats:styled-content>2\/D<\/jats:styled-content>3 receptor binding is localised to the NA<\/jats:styled-content>cbS of trait\u2010like impulsive rats and is accompanied by reduced binding for DAT<\/jats:styled-content>. Alterations in binding for D<\/jats:styled-content>1 receptors in the NA<\/jats:styled-content>cbC and GABA<\/jats:styled-content>(A) receptors in the anterior cingulate cortex demonstrate additional markers and putative mechanisms underlying the expression of behavioural impulsivity.<\/jats:p>","DOI":"10.1111\/ejn.12146","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T15:39:15Z","timestamp":1359733155000},"page":"1519-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Dopaminergic and GABA<\/scp>\u2010ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex"],"prefix":"10.1111","volume":"37","author":[{"given":"Bianca","family":"Jupp","sequence":"first","affiliation":[{"name":"Behavioural and Clinical Neuroscience Institute University of Cambridge Cambridge UK"},{"name":"Department of Psychology University of Cambridge Downing St Cambridge CB2 3EB UK"},{"name":"Florey Institute for Neuroscience and Mental Health The University of Melbourne Parkville Vic. 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