{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:59:44Z","timestamp":1791557984603,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T00:00:00Z","timestamp":1364688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Withdrawal from a chronic period of alcohol consumption is commonly associated with the manifestation of depression, potentially exerting a significant influence on treatment prospects and increasing the likelihood of relapse. Better therapeutic strategies need to be developed to assist with rehabilitation. Here, we report the detection of depression\u2010related behaviours in a mouse model of 6\u2010week free\u2010choice ethanol (10%, v\/v) consumption followed by 2\u2010week abstinence. Mice abstinent from alcohol showed increased immobility time on the forced\u2010swim test, reduced saccharin consumption and increased latency to feed in the novelty\u2010suppressed feeding test. By comparison, there was no significant effect on anxiety\u2010related behaviours as determined by testing on the light\u2013dark box and elevated plus maze. We found that the provision of running\u2010wheels through the duration of abstinence attenuated depressive behaviour in the forced\u2010swim and novelty\u2010suppressed feeding tests, and increased saccharin consumption. Given the link between withdrawal from addictive substances and depression, this model will be useful for the study of the pathophysiology underlying alcohol\u2010related depression. The findings of this study establish an interaction between physical activity and the development of behavioural changes following cessation of alcohol consumption that could have implications for the development of rehabilitative therapies.<\/jats:p>","DOI":"10.1111\/ejn.12195","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T04:17:21Z","timestamp":1364789841000},"page":"1803-1810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Depression\u2010related behaviours displayed by female <scp>C<\/scp>57<scp>BL<\/scp>\/6<scp>J<\/scp> mice during abstinence from chronic ethanol consumption are rescued by wheel\u2010running"],"prefix":"10.1111","volume":"37","author":[{"given":"Terence Y.","family":"Pang","sequence":"first","affiliation":[{"name":"Behavioural Neurosciences Division Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Renoir","sequence":"additional","affiliation":[{"name":"Behavioural Neurosciences Division Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Behavioural Neurosciences Division Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Behavioural Neurosciences Division Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Behavioural Neurosciences Division Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic. 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005286"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301429"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10899-012-9320-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.02.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000149977.95306.3A"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20621"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005122"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20683"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.09.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.127"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.03.072"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(04)00081-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008142"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2003.64.375"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.01.017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.12.047"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1402-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.12.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012769"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20634"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.021"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00823.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300498"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2006.00270.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830160031005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000131976.40428.8F"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2283011"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.05.001"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01634.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-008-9246-8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.007"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.2"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3063-04.2004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.77"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03552.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2012.00788.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn385"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02452.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.10.007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/6368"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301001"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02308.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190043026"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.10.003"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.014"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.07.036"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05120.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00015"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.06.005"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300852"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1982.43.380"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806889105"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.51"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.90"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990472"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-186"},{"key":"e_1_2_6_60_1","first-page":"CD002295","article-title":"Exercise interventions for smoking cessation","volume":"1","author":"Ussher M.H.","year":"2012","journal-title":"Cochrane Db. Syst. Rev."},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2009.02.003"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.03889.x"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2012.663327"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.02.006"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.12195","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.12195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T22:10:14Z","timestamp":1697667014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.12195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,31]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/ejn.12195"],"URL":"https:\/\/doi.org\/10.1111\/ejn.12195","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,31]]},"assertion":[{"value":"2012-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}