{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:32:57Z","timestamp":1791354777521,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T00:00:00Z","timestamp":1365292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is a respiratory condition occurring during sleep characterised by repeated collapse of the upper airway. Patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> show altered brain structure and function that may manifest as impaired neuroplasticity. We assessed this hypothesis in 13 patients with moderate\u2010to\u2010severe OSA and 11 healthy control subjects. Transcranial magnetic stimulation was used to induce and measure neuroplastic changes in the motor cortex by assessing changes in motor\u2010evoked potentials (MEPs) in a hand muscle. Baseline measurements of cortical excitability included active (AMT) and resting motor thresholds (RMT), and the maximal stimulator output producing a 1\u2010mV MEP. Intracortical inhibition (ICI) was investigated with short\u2010 and long\u2010interval ICI paradigms (SICI and LICI, respectively), and neuroplastic changes were induced using continuous theta burst stimulation (cTBS). At baseline, differences were found between groups for RMT (9.5% maximal stimulator output higher in OSA) and 1\u2010mV MEPs (10.3% maximal stimulator output higher in OSA), but not AMT. No differences were found between groups for SICI or LICI. The response to cTBS was different between groups, with control subjects showing an expected reduction in MEP amplitude after cTBS, whereas the MEPs in patients with OSA did not change. The lack of response to cTBS suggests impaired long\u2010term depression\u2010like neuroplasticity in patients with OSA, which may be a consequence of sleep fragmentation or chronic blood gas disturbance in sleep. This reduced neuroplastic capacity may have implications for the learning, retention or consolidation of motor skills in patients with OSA.<\/jats:p>","DOI":"10.1111\/ejn.12203","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T03:56:44Z","timestamp":1365393404000},"page":"1844-1852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Motor cortex plasticity induced by theta burst stimulation is impaired in patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"37","author":[{"given":"George M.","family":"Opie","sequence":"first","affiliation":[{"name":"Discipline of Physiology School of Medical Sciences The University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Catcheside","sequence":"additional","affiliation":[{"name":"Discipline of Physiology School of Medical Sciences The University of Adelaide Adelaide SA Australia"},{"name":"Adelaide Institute for Sleep Health Repatriation General Hospital Daw Park SA Australia"},{"name":"Faculty of Health Sciences School of Medicine Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar A.","family":"Usmani","sequence":"additional","affiliation":[{"name":"Adelaide Institute for Sleep Health Repatriation General Hospital Daw Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Ridding","sequence":"additional","affiliation":[{"name":"Robinson Institute School of Paediatrics and Reproductive Health University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Semmler","sequence":"additional","affiliation":[{"name":"Discipline of Physiology School of Medical Sciences The University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2356"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.5.936"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.027"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.06.005"},{"key":"e_1_2_6_6_1","first-page":"176","article-title":"Pathophysiology & genetics of obstructive sleep apnoea","volume":"131","author":"Campana L.","year":"2010","journal-title":"Indian J. 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