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However, whether regenerative endogenous neurogenesis is taking place in the mammalian <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> of parkinsonian and non\u2010parkinsonian brains remains of debate. Here, we tested whether proliferating cells in the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> and their neurogenic potential would be affected by anti\u2010inflammatory treatment under physiological conditions and in the 6\u2010hydroxy\u2010dopamine (6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>) Parkinson's disease mouse model. We report that the majority of newly generated nigral cells are positive for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oublecortin (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>cx), which is an often used marker for neural progenitor cells. Yet, <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>cx expression levels in these cells were much lower than in neural progenitor cells of the subventricular zone and the dentate gyrus neural progenitor cells. Furthermore, these newly generated nigral cells are negative for neuronal lineage markers such as <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>u<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eu<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>. Therefore, their neuronal commitment is questionable. Instead, we found evidence for oligodendrogenesis and astrogliosis in the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>. Finally, neither short\u2010term nor long\u2010term inhibition of neuroinflammation by <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>inocycline\u2010 or 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>\u2010induced lesion affected the numbers of newly generated cells in our disease paradigm. Our findings of adult generated <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>cx<jats:sup>+<\/jats:sup> cells in the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> add important data for understanding the cellular composition and consequently the regenerative capacity of the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejn.12269","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T09:23:39Z","timestamp":1370424219000},"page":"2684-2692","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The majority of newly generated cells in the adult mouse substantia nigra express low levels of <scp>D<\/scp>oublecortin, but their proliferation is unaffected by 6\u2010<scp>OHDA<\/scp>\u2010induced nigral lesion or <scp>M<\/scp>inocycline\u2010mediated inhibition of neuroinflammation"],"prefix":"10.1111","volume":"38","author":[{"given":"Maik M. A.","family":"Worlitzer","sequence":"first","affiliation":[{"name":"Westf\u00e4lische Wilhelms\u2010Universit\u00e4t M\u00fcnster ZMBE Institute of Cell Biology Stem Cell Biology and Regeneration Group Von\u2010Esmarch\u2010Str. 56 48149 M\u00fcnster Germany"},{"name":"Interdisciplinary Center for Clinical Research (IZKF) M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Viel","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Clinical Research (IZKF) M\u00fcnster M\u00fcnster Germany"},{"name":"European Institute for Molecular Imaging \u2013 EIMI M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas H.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Clinical Research (IZKF) M\u00fcnster M\u00fcnster Germany"},{"name":"European Institute for Molecular Imaging \u2013 EIMI M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens C.","family":"Schwamborn","sequence":"additional","affiliation":[{"name":"Westf\u00e4lische Wilhelms\u2010Universit\u00e4t M\u00fcnster ZMBE Institute of Cell Biology Stem Cell Biology and Regeneration Group Von\u2010Esmarch\u2010Str. 56 48149 M\u00fcnster Germany"},{"name":"Interdisciplinary Center for Clinical Research (IZKF) M\u00fcnster M\u00fcnster Germany"},{"name":"Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Esch\u2010Belval Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21582"},{"key":"e_1_2_6_3_1","first-page":"279","article-title":"Neurogenesis in substantia nigra of parkinsonian brains?","volume":"73","author":"Arias\u2010Carrion O.","year":"2009","journal-title":"J. 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