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In an earlier study, we confirmed that the <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>icd2<\/jats:italic> interval harbors gene(s) conferring strong protection against seizure\u2010induced cell death through the creation of the <jats:styled-content style=\"fixed-case\">FVB<\/jats:styled-content>.B6\u2010<jats:italic>Sicd2<\/jats:italic> congenic strain, and created three interval\u2010specific congenic lines (<jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>s) that encompass <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>icd2<\/jats:italic> on chromosome 15 to fine\u2010map this locus. To further localise this <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>icd2 <\/jats:italic><jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>, an additional congenic line carrying overlapping intervals of the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6 segment was created (<jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\u20104), and compared with the previously created <jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\u20101\u2013<jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\u20103 and assessed for seizure\u2010induced cell death phenotype. Whereas all of the <jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>s showed reduced cell death associated with the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6 phenotype, <jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\u20104, showed the most extensive reduction in seizure\u2010induced cell death throughout all hippocampal subfields. In order to characterise the susceptibility loci on <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>icd2<\/jats:italic> by use of this <jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content> and identify compelling candidate genes, we undertook an integrative genomic strategy of comparing exon transcript abundance in the hippocampus of this newly developed chromosome 15 subcongenic line (<jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\u20104) and <jats:styled-content style=\"fixed-case\">FVB<\/jats:styled-content>\u2010like littermates. We identified 10 putative candidate genes that are alternatively spliced between the strains and may govern strain\u2010dependent differences in susceptibility to seizure\u2010induced excitotoxic cell death. These results illustrate the importance of identifying transcriptomics variants in expression studies, and implicate novel candidate genes conferring susceptibility to seizure\u2010induced cell death.<\/jats:p>","DOI":"10.1111\/ejn.12351","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T04:20:47Z","timestamp":1378268447000},"page":"3679-3690","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microarray\u2010assisted fine mapping of quantitative trait loci on chromosome 15 for susceptibility to seizure\u2010induced cell death in mice"],"prefix":"10.1111","volume":"38","author":[{"given":"P. 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