{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:08:22Z","timestamp":1789380502058,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study aims to investigate the potential of brief electrical stimulation (\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    ; 3\u00a0V, 20\u00a0Hz, 20\u00a0min) in improving functional recovery in delayed nerve injury repair (\n                    <jats:styled-content style=\"fixed-case\">DNIR<\/jats:styled-content>\n                    ). The sciatic nerve of Sprague Dawley rats was transected, and the repair of nerve injury was delayed for different time durations (2, 4, 12 and 24\u00a0weeks). Brief depolarizing\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    was applied to the proximal nerve stump when the transected nerve stumps were bridged with a hollow nerve conduit (5\u00a0mm in length) after delayed periods. We found that the diameter and number of regenerated axons, the thickness of myelin sheath, as well as the number of Fluoro\u2010Gold retrograde\u2010labeled motoneurons and sensory neurons were significantly increased by\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    , suggesting that brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    to proximal nerve stumps is capable of promoting nerve regeneration in\n                    <jats:styled-content style=\"fixed-case\">DNIR<\/jats:styled-content>\n                    with different delayed durations, with the longest duration of 24\u00a0weeks. In addition, the amplitude of compound muscle action potential (gastrocnemius muscle) and nerve conduction velocity were also enhanced, and gastrocnemius muscle atrophy was partially reversed by brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    , indicating that brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    to proximal nerve stump was able to improve functional recovery in\n                    <jats:styled-content style=\"fixed-case\">DNIR<\/jats:styled-content>\n                    . Furthermore, brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    was capable of increasing brain\u2010derived neurotrophic factor (\n                    <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>\n                    ) expression in the spinal cord in\n                    <jats:styled-content style=\"fixed-case\">DNIR<\/jats:styled-content>\n                    , suggesting that\n                    <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>\n                    \u2010mediated neurotrophin signaling might be one of the contributing factors to the beneficial effect of brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    on\n                    <jats:styled-content style=\"fixed-case\">DNIR<\/jats:styled-content>\n                    . In conclusion, the present findings indicate the potential of using brief\n                    <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\n                    as a useful method to improve functional recovery for delayed repair of peripheral nerve lesions.\n                  <\/jats:p>","DOI":"10.1111\/ejn.12370","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:17:48Z","timestamp":1381529868000},"page":"3691-3701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Electrical stimulation accelerates nerve regeneration and functional recovery in delayed peripheral nerve injury in rats"],"prefix":"10.1111","volume":"38","author":[{"given":"Jinghui","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics Xijing Hospital The Fourth Military Medical University Xi'an 710032 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