{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:49:25Z","timestamp":1762375765062},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Estrogen has been shown to enhance the effects of antipsychotics in humans. To investigate the mechanisms of how this may occur, the current study examined estradiol's effects on dopaminergic transmission and behavior in amphetamine\u2010sensitized and non\u2010sensitized female rats. Sixty\u2010four ovariectomized female Sprague\u2013Dawley rats were used for this study. Half of the rats were sensitized to four once\u2010daily injections of 1\u00a0mg\/kg amphetamine and the other half served as controls. Rats received chronic administration of either low\u2010dose haloperidol (0.25\u00a0mg\/kg\/day) or saline vehicle via osmotic minipumps implanted subcutaneously. The groups were further subdivided with respect to estradiol treatment: low chronic estrogen (subcutaneous estradiol implant, 0.36\u00a0mg\/pellet: 90\u2010day release, plus an additional oil vehicle injection every second day) and high pulsatile estrogen (subcutaneous estradiol implant plus an additional 10\u00a0\u03bcg\/kg estradiol injection every second day). Motor activity was assessed at day\u00a02 and day\u00a012 during haloperidol treatment, while nucleus accumbens dopamine availability was assessed via microdialysis 10\u00a0days into antipsychotic treatment. Haloperidol treatment along with high, but not low, estradiol replacement was effective in reducing amphetamine\u2010induced locomotor activity in sensitized rats. High estradiol treatment also augmented the effects of chronic haloperidol in reducing dopaminergic release in sensitized rats. These data suggest that estradiol levels affect both the behavioral and the dopamine responses to chronic antipsychotic treatment.<\/jats:p>","DOI":"10.1111\/ejn.12401","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T14:34:25Z","timestamp":1382711665000},"page":"257-265","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Estrogen potentiates the behavioral and nucleus accumbens dopamine response to continuous haloperidol treatment in female rats"],"prefix":"10.1111","volume":"39","author":[{"given":"Dan","family":"Madularu","sequence":"first","affiliation":[{"name":"Department of Psychology Centre for Studies in Behavioural Neurobiology Concordia University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqqas M.","family":"Shams","sequence":"additional","affiliation":[{"name":"Department of Psychology Centre for Studies in Behavioural Neurobiology Concordia University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne G.","family":"Brake","sequence":"additional","affiliation":[{"name":"Department of Psychology Centre for Studies in Behavioural Neurobiology Concordia University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00161-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1458"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380979"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91547-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.093"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90137-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00125-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(91)90038-Q"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90141-Y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(80)90095-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","unstructured":"D. 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