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Studies have begun to suggest that such influences occur in conditions such as fibromyalgia (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>), but it is not clear whether this is unique to <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> pain or common to other forms of chronic pain, such as that associated with osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>). We assessed top\u2010down processes by measuring anticipation\u2010evoked potentials and their estimated sources, just prior (&lt;\u00a0500\u00a0ms) to laser heat pain stimulation, in 16 patients with <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>, 16 patients with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and 15 healthy participants, by using whole\u2010brain statistical parametric mapping. Clinical pain and psychological coping factors (pain catastrophizing, anxiety, and depression) were well matched between the patient groups, such that these did not confound our comparisons between <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> patients. For the same level of heat pain, insula activity was significantly higher in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients than in the other two groups during anticipation, and correlated with the intensity and extent of reported clinical pain. However, the same anticipatory insula activity also correlated with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> pain, and with the number of tender points across the two patient groups, suggesting common central mechanisms of tenderness. Activation in the dorsolateral prefrontal cortex was reduced during anticipation in both patient groups, and was related to less effective psychological coping. Our findings suggest common neural correlates of pain and tenderness in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> that are enhanced in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> but not unique to this condition.<\/jats:p>","DOI":"10.1111\/ejn.12420","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T05:59:21Z","timestamp":1384322361000},"page":"663-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["When the brain expects pain: common neural responses to pain anticipation are related to clinical pain and distress in fibromyalgia and osteoarthritis"],"prefix":"10.1111","volume":"39","author":[{"given":"Christopher A.","family":"Brown","sequence":"first","affiliation":[{"name":"Human Pain Research Group Institute of Brain Behaviour and Mental Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"El\u2010Deredy","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony K. 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