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In support of this essential function, <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> modulates synaptic plasticity in different brain areas, including the striatum. Many drugs used for cognitive enhancement are psychostimulants, such as methylphenidate (<jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content>), which enhance <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> levels. <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> treatment is of interest during adolescence, a period of enhanced neurodevelopment during which the <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> system is in a state of flux. Recent epidemiological studies report the co\u2010abuse of <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> and ethanol in adolescents and young adults. Although repeated <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> treatment produces enduring changes that affect subsequent behavioral responses to other psychostimulants, few studies have investigated the interactions between <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> and ethanol. Here we addressed whether chronic therapeutic exposure to <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> during adolescence predisposed mice to an altered response to ethanol and whether this was accompanied by altered <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release and striatal plasticity. C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content> mice were administered <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> (3\u20136\u00a0mg\/kg\/day) via the drinking water between post\u2010natal days 30 and 60. Voltammetry experiments showed that sufficient brain <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> concentrations were achieved during adolescence in mice to increase the <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> clearance in adulthood. The treatment also increased long\u2010term depression and reduced the effects of ethanol on striatal synaptic responses. Although the injection of 0.4 or 2\u00a0g\/kg ethanol dose\u2010dependently decreased locomotion in control mice, only the higher dose decreased locomotion in <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content>\u2010treated mice. These results suggested that the administration of <jats:styled-content style=\"fixed-case\">MPH<\/jats:styled-content> during development promoted long\u2010term effects on synaptic plasticity in forebrain regions targeted by <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>. These changes in plasticity might, in turn, underlie alterations in behaviors controlled by these brain regions into adulthood.<\/jats:p>","DOI":"10.1111\/ejn.12426","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T14:21:22Z","timestamp":1384784482000},"page":"548-556","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chronic methylphenidate exposure during adolescence reduces striatal synaptic responses to ethanol"],"prefix":"10.1111","volume":"39","author":[{"given":"Nicole A.","family":"Crowley","sequence":"first","affiliation":[{"name":"Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health 5625 Fishers Lane Rockville MD 20852 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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