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In addition to their molecular diversity, variations in their distributions and densities on the axo\u2010somato\u2010dendritic surface of neurons are key parameters in determining their functional impact. Despite extensive electrophysiological and anatomical investigations, the exact location and densities of most K\n                    <jats:sup>+<\/jats:sup>\n                    channels in small subcellular compartments are still unknown. Here we aimed at providing a quantitative surface map of two delayed\u2010rectifier (Kv1.1 and Kv2.1) and one G\u2010protein\u2010gated inwardly rectifying (Kir3.2) K\n                    <jats:sup>+<\/jats:sup>\n                    channel subunits on hippocampal\n                    <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n                    1 pyramidal cells (\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    s). Freeze\u2010fracture replica immunogold labelling was employed to determine the relative densities of these K\n                    <jats:sup>+<\/jats:sup>\n                    channel subunits in 18 axo\u2010somato\u2010dendritic compartments. Significant densities of the Kv1.1 subunit were detected on axon initial segments (\n                    <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>\n                    s) and axon terminals, with an approximately eight\u2010fold lower density in the latter compartment. The Kv2.1 subunit was found in somatic, proximal dendritic and\n                    <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>\n                    plasma membranes at approximately the same densities. This subunit has a non\u2010uniform plasma membrane distribution; Kv2.1 clusters are frequently adjacent to, but never overlap with,\n                    <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                    ergic synapses. A quasi\u2010linear increase in the Kir3.2 subunit density along the dendrites of\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    s was detected, showing no significant difference between apical dendritic shafts, oblique dendrites or dendritic spines at the same distance from the soma. Our results demonstrate that each subunit has a unique cell\u2010surface distribution pattern, and predict their differential involvement in synaptic integration and output generation at distinct subcellular compartments.\n                  <\/jats:p>","DOI":"10.1111\/ejn.12526","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T09:29:33Z","timestamp":1394184573000},"page":"1771-1783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Distinct axo\u2010somato\u2010dendritic distributions of three potassium channels in\n                    <scp>CA<\/scp>\n                    1 hippocampal pyramidal cells"],"prefix":"10.1111","volume":"39","author":[{"given":"Tekla","family":"Kirizs","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Neurophysiology Institute of Experimental Medicine Hungarian Academy of Sciences Szigony Street 43 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kerti\u2010Szigeti","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Neurophysiology Institute of Experimental Medicine Hungarian Academy of Sciences Szigony Street 43 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lorincz","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Neurophysiology Institute of Experimental Medicine Hungarian Academy of Sciences Szigony Street 43 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Nusser","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Neurophysiology Institute of Experimental Medicine Hungarian Academy of Sciences Szigony Street 43 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05153.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00476-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150339"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012119"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5312-04.2005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.3.1007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00519-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00019.xm"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-9-66"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07886.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06552.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1242\/jcs.108.11.3443","article-title":"Freeze\u2010fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. 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