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The neural circuitry underlying emotional learning is known to involve the amygdala and hippocampus, although the precise impact of amyloid pathology on the interaction between these brain regions remains unclear. Recent evidence suggests that Tg2576 mice, which express a human amyloid precursor protein (<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>) mutation associated with early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, demonstrate normal acquisition of conditioned freezing to auditory and contextual stimuli paired with footshock. However, examination of the expression of c\u2010Fos revealed altered neural network activity in transgenic mice. In the present study we examined the effects of the <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> mutation on the expression of c\u2010Fos following the retrieval of emotional memories. To this end, stimulus\u2010induced cellular activity was measured by analysing expression of the immediate\u2010early gene c\u2010Fos after the retrieval of auditory or contextual fear memories. To characterize regional interdependencies of c\u2010Fos expression, structural equation modelling was used to compare patterns of neural network activity. Consistent with previous findings, Tg2576 mice displayed reduced freezing elicited by the auditory stimulus but not by the conditioning context. Interestingly, the analysis of c\u2010Fos expression revealed that the <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe mutation disrupted dentate gyrus and amygdala function, as well as altering the influence of these regions on the neural network dynamics activated during context memory retrieval. These results provide novel insight into the influence of excess amyloid production on neural network activity during memory retrieval.<\/jats:p>","DOI":"10.1111\/ejn.12527","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T02:03:40Z","timestamp":1395021820000},"page":"1690-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u03b2\u2010Amyloid pathology alters neural network activation during retrieval of contextual fear memories in a mouse model of Alzheimer's disease"],"prefix":"10.1111","volume":"39","author":[{"given":"Mariah J.","family":"Lelos","sequence":"first","affiliation":[{"name":"School of Psychology Cardiff University Park Place Cardiff Wales CF10 3AT UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Good","sequence":"additional","affiliation":[{"name":"School of Psychology Cardiff University Park Place Cardiff Wales CF10 3AT UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07042.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.08.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.06.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00709.1995"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.07.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-03-02301.1995"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91669-R"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2693-05.2005"},{"key":"e_1_2_8_12_1","first-page":"295","article-title":"Brain c\u2010Fos immunocytochemistry and cytochrome oxidase histochemistry after a fear conditioning task","volume":"19","author":"Conejo N.M.","year":"2007","journal-title":"Psicothema"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200301000-00001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.51002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.15.030192.002033"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.06.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200164200"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.05.040"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2230-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21176"},{"key":"e_1_2_8_21_1","unstructured":"Fan X. 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