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However, the underlying mechanisms for this loss are still not clear. Here we tested the hypothesis that, in albino rats, the retinal input to the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> lacks direction selectivity and, as a consequence, neurons in the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> are direction non\u2010selective. We investigated <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>\u2010center direction\u2010selective retinal ganglion cells, the major input to the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>, in pigmented Long Evans and albino Wistar rats using extracellular <jats:italic>in vitro<\/jats:italic> patch\u2010clamp techniques. To visualise putative <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>\u2010projecting direction\u2010selective ganglion cells, we retrogradely labeled them by injection of the infrared\u2010sensitive dye indocyanine green into the medial terminal nucleus of the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>. The present study is the first to present physiological evidence for retinal <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>\u2010center direction\u2010selective ganglion cells in rat. Our results show that, in albinotic and pigmented rats, <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>\u2010center retinal ganglion cells projecting to the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> are similarly direction\u2010selective, suggesting that the optokinetic deficit must be caused by the abolition of direction selectivity in the <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> itself.<\/jats:p>","DOI":"10.1111\/ejn.12572","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T10:04:52Z","timestamp":1396519492000},"page":"2274-2282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal ganglion cells projecting to the accessory optic system in optokinetic blind albinotic rats are direction\u2010selective"],"prefix":"10.1111","volume":"40","author":[{"given":"Martin","family":"Krause","sequence":"first","affiliation":[{"name":"Allgemeine Zoologie &amp; Neurobiologie Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Distler","sequence":"additional","affiliation":[{"name":"Allgemeine Zoologie &amp; Neurobiologie Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus\u2010Peter","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Allgemeine Zoologie &amp; Neurobiologie Ruhr\u2010University Bochum Bochum Germany"},{"name":"Tierphysiologie Ruhr\u2010Universit\u00e4t Bochum Universit\u00e4tsstr. 150 ND 5\/26 Bochum 44780 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"4080","article-title":"Periodic alternating nystagmus in humans with albinism","volume":"35","author":"Abadi R.V.","year":"1994","journal-title":"Invest. 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