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However, it is unclear whether posterior cortical volume loss contributes to abnormal neural activity, and whether activity changes predict cognitive dysfunction. Using magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), we investigated brain structure and visual network activity at rest in patients with early <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). The symbol digit modalities test (<jats:styled-content style=\"fixed-case\">SDMT<\/jats:styled-content>) and subtests of the Visual Object and Space Perception Battery were completed offline. For functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data, a group independent component analysis was used. Voxel\u2010based morphometry was employed to assess regional brain atrophy, and \u2018biological parametric mapping\u2019 analyses were included to investigate the impact of atrophy on neural activity. Patients showed significantly worse visuomotor and visual object performance than controls. Structural analyses confirmed occipitotemporal atrophy. In patients and controls, two spatiotemporally distinct visual systems were identified. Patients showed decreased activity in the left fusiform cortex, and increased left cerebellar activity. These findings remained stable after correction for brain atrophy. Lower fusiform cortex activity was associated with lower <jats:styled-content style=\"fixed-case\">SDMT<\/jats:styled-content> performance and with higher disease burden scores. These associations were absent when cerebellar function was related to task performance and disease burden. The results of this study suggest that regionally specific functional abnormalities of the visual system can account for the worse visuomotor cognition in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. However, occipital volume changes cannot sufficiently explain abnormal neural function in these patients.<\/jats:p>","DOI":"10.1111\/ejn.12575","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T09:13:14Z","timestamp":1396516394000},"page":"2417-2426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Visual system integrity and cognition in early Huntington's disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Robert C.","family":"Wolf","sequence":"first","affiliation":[{"name":"Department of General Psychiatry Center for Psychosocial Medicine University of Heidelberg Vo\u00dfstra\u00dfe 4 Heidelberg 69115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cognitive Systems at UniTN  Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Vasic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy III Ulm University  Ulm Germany"},{"name":"Department for Forensic Psychiatry and Psychotherapy at the District Hospital G\u00fcnzburg Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Maria","family":"Baldas","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Ratheiser","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Bernhard Landwehrmeyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte S.","family":"Depping","sequence":"additional","affiliation":[{"name":"Department of General Psychiatry Center for Psychosocial Medicine University of Heidelberg Vo\u00dfstra\u00dfe 4 Heidelberg 69115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A.","family":"Thomann","sequence":"additional","affiliation":[{"name":"Department of General Psychiatry Center for Psychosocial Medicine University of Heidelberg Vo\u00dfstra\u00dfe 4 Heidelberg 69115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Sprengelmeyer","sequence":"additional","affiliation":[{"name":"School of Psychology and Neuroscience University of St Andrews  St Andrews UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd D.","family":"S\u00fcssmuth","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Orth","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnn.0000152205.79033.73"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390903313564"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.06.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_6_7_1","first-page":"2","article-title":"Region of interest analysis using an SPM toolbox [abstract]. 8th International Conference on Functional Mapping of the Human Brain","volume":"16","author":"Brett M.","year":"2002","journal-title":"NeuroImage"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.09.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20581"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.112"},{"key":"e_1_2_6_12_1","first-page":"401","article-title":"Comparison of blind source separation algorithms for FMRI using a new Matlab toolbox: GIFT","volume":"5","author":"Correa N.","year":"2005","journal-title":"Int. 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