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Little is known about the progression from amnestic mild cognitive impairment (a\n                    <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                    ; isolated memory loss) to\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    . Studies have found impairments in mild\u2010stage AD and aMCI in specific tests of executive function. Here, we used objective saccade tasks to determine if they can effectively assess executive function deficits otherwise assessed by neuropsychological testing. To determine which executive function deficits the saccade tasks are most sensitive to, we also investigated the relationship between performance on saccade tasks and neuropsychological test scores. Twenty\u2010two a\n                    <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                    patients (63\u201390\u00a0years), 24 mild AD patients (61\u201387\u00a0years) and 76 healthy controls (60\u201385\u00a0years) performed a battery of neuropsychological tests, and two saccade tasks designed to probe sensory, motor and cognitive function. The prosaccade task requires a fast, automatic saccade toward an eccentric visual stimulus. The antisaccade task requires additional executive processing to inhibit the automatic prosaccade toward the stimulus, so that a voluntary saccade can be initiated to a location opposite the stimulus. Antisaccade performance was impaired similarly in a\n                    <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    patients relative to controls; both groups were slower to initiate correct antisaccades and they made more direction errors (erroneous prosaccades), suggesting similar brain deficits. Scores on the Stroop task were inversely correlated with the percentage of short\u2010latency direction errors in the antisaccade task for controls and a\n                    <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                    patients, whereas other more global measures of executive function were not related to saccade measures in any subject group. Our results show that the antisaccade task is useful for detecting executive dysfunction in a\n                    <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    , especially dysfunction in selective attention. Saccade tasks may therefore have potential to assess executive dysfunction when use of neuropsychological tests is not possible.\n                  <\/jats:p>","DOI":"10.1111\/ejn.12617","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T23:23:53Z","timestamp":1401665033000},"page":"2000-2013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Saccade deficits in amnestic mild cognitive impairment resemble mild Alzheimer's disease"],"prefix":"10.1111","volume":"39","author":[{"given":"Alicia","family":"Peltsch","sequence":"first","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University Kingston ON K7L 3N6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Hemraj","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University Kingston ON K7L 3N6 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