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Twenty patients with Alzheimer's disease underwent positron emission tomography using <jats:sup>11<\/jats:sup>C\u2010Pittsburgh Compound B (<jats:sup>11<\/jats:sup>C\u2010PiB) to quantify the A\u03b2 deposition. Volumes\u2010of\u2010interest analyses were performed on the ventral striatum (VST), pre\u2010commissural dorsal caudate (pre\u2010DCA), post\u2010commissural caudate (post\u2010CA), pre\u2010commissural dorsal putamen (pre\u2010DPU), and post\u2010commissural putamen (post\u2010PU), followed by exploratory voxel\u2010wise analyses. Volumes\u2010of\u2010interest analyses of <jats:sup>11<\/jats:sup>C\u2010PiB binding showed: VST &gt; pre\u2010DPU (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004), VST &gt; pre\u2010DCA (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), pre\u2010DPU &gt; post\u2010PU (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), and pre\u2010DCA &gt; post\u2010CA (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), consistent with visual inspection of the <jats:sup>11<\/jats:sup>C\u2010PiB images. Exploratory voxel\u2010wise analyses of <jats:sup>11<\/jats:sup>C\u2010PiB binding showed a positive correlation between the VST and the medial part of the orbitofrontal area (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01 family\u2010wise error corrected). This study confirmed that there were ventral &gt; dorsal, and anterior &gt; posterior gradients of A\u03b2 deposition in patients with Alzheimer's disease, and provided the first evidence of a robust correlation between A\u03b2 deposition levels in the VST and the medial part of the orbitofrontal area. There are well\u2010known anatomical and functional links between these areas. These findings indicated that brain A\u03b2 deposition was not randomly distributed, but had characteristic patterns related to anatomical connectivity and\/or functional networks.<\/jats:p>","DOI":"10.1111\/ejn.12633","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T07:04:35Z","timestamp":1401692675000},"page":"2701-2706","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regional analysis of striatal and cortical amyloid deposition in patients with <scp>A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Kenji","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology 35\u20102 Sakae\u2010cho Itabashi\u2010ku Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichi","family":"Ishiwata","sequence":"additional","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology 35\u20102 Sakae\u2010cho Itabashi\u2010ku Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Toyohara","sequence":"additional","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology 35\u20102 Sakae\u2010cho Itabashi\u2010ku Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Geriatric Hospital 35\u20102 Sakae\u2010cho Itabashi\u2010ku Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology 35\u20102 Sakae\u2010cho Itabashi\u2010ku Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.431"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111340"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199005000-00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00056-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1997.tb01302.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90110-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90391-L"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn041"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90027-U"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.02.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0532-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244749.20056.d4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000925)425:3<447::AID-CNE9>3.0.CO;2-V"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn016"},{"key":"e_1_2_8_21_1","first-page":"424","article-title":"Ventral striatal volume is associated with cognitive decline in older people: a population based MR\u2010study","volume":"33","author":"Jong L.W.","year":"2012","journal-title":"Neurobiol. 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