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Although the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 regions have been extensively studied, for years the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region has primarily been viewed as a linking area between the two. However, the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region is known to have distinct neurochemical and structural features that are different from the other parts of the hippocampus and in recent years it has been suggested that the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region may play a role in the formation and\/or recall of olfactory\u2010based memories needed for normal social behavior. Although this hypothesis has been supported by hippocampal lesion studies that have included the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region, no studies have attempted to specifically lesion the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region of the hippocampus in mice to determine the effects on social recognition memory and olfaction. To fill this knowledge gap, we sought to perform excitotoxic <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2010methyl\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010aspartate lesions of the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region and determine the effects on social recognition memory. We predicted that lesions of the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region would impair social recognition memory. We then went on to test olfaction in <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2\u2010lesioned mice, as social memory requires a functional olfactory system. Consistent with our prediction, we found that <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2\u2010lesioned animals had impaired social recognition. These findings are significant because they confirmed that the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>2 region of the hippocampus is a part of the neural circuitry that regulates social recognition memory, which may have implications for our understanding of the neural regulation of social behavior across species.<\/jats:p>","DOI":"10.1111\/ejn.12689","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T10:44:07Z","timestamp":1407753847000},"page":"3294-3301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":238,"title":["Lesions to the <scp>CA<\/scp>2 region of the hippocampus impair social memory in mice"],"prefix":"10.1111","volume":"40","author":[{"given":"Erica L.","family":"Stevenson","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrinology and Behavior Department of Biological Sciences and the School of Biomedical Sciences Kent State University 121 Cunningham Hall Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrinology and Behavior Department of Biological Sciences and the School of Biomedical Sciences Kent State University 121 Cunningham Hall Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.051"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2009.03.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.06.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00138-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005706"},{"key":"e_1_2_6_8_1","first-page":"344","article-title":"Rodent pheromones","volume":"4","author":"Bronson F.H.","year":"1971","journal-title":"Biol. 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