{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:48:27Z","timestamp":1790315307117,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies conducted in patients with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease have reported that the degeneration of substantia nigra dopaminergic neurons, which are essential for motor control, is associated with the loss of hypothalamic orexin neurons, which are involved in sleep regulation. In order to better explore the mutual interactions between these two systems, we wished to determine in macaques: (i) if the two orexin peptides, orexin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and orexin\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, are distributed in the same hypothalamic cells and if they are localized in nerve terminals that project onto nigral dopaminergic neurons, and (ii) if there is a loss of orexin neurons in the hypothalamus and of orexin fibers innervating nigral dopaminergic neurons in macaques rendered parkinsonian by 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (<jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>) intoxication. We showed that virtually all cells stained for orexin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> in the hypothalamus co\u2010expressed orexin\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. Numerous terminals stained for both orexin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and orexin\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> immunoreactivity that innervated the whole extent of the ventral tegmental area and substantia nigra pars compacta were found in close proximity to tyrosine hydroxylase\u2010immunoreactive dendrites. These data indicate that orexin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and orexin\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> peptides are in a position to play a role in controlling the activity of nigral dopaminergic neurons. However, no loss of orexin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> or orexin\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> neurons in the hypothalamus and no loss of orexin fibers in the substantia nigra pars compacta was found in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated macaques when compared with control macaques. We conclude that a relatively selective dopaminergic lesion, such as that performed in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated macaques, is not sufficient to induce a loss of hypothalamic orexin neurons.<\/jats:p>","DOI":"10.1111\/ejn.12761","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T13:04:32Z","timestamp":1413637472000},"page":"129-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sparing of orexin\u2010<scp>A<\/scp> and orexin\u2010<scp>B<\/scp> neurons in the hypothalamus and of orexin fibers in the substantia nigra of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2010treated macaques"],"prefix":"10.1111","volume":"41","author":[{"given":"Manale","family":"Bensaid","sequence":"first","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. Paris 06 Sorbonne Universit\u00e9s F\u201075013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Tand\u00e9","sequence":"additional","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. Paris 06 Sorbonne Universit\u00e9s F\u201075013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fabre","sequence":"additional","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. Paris 06 Sorbonne Universit\u00e9s F\u201075013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick P.","family":"Michel","sequence":"additional","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. Paris 06 Sorbonne Universit\u00e9s F\u201075013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne C.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. Paris 06 Sorbonne Universit\u00e9s F\u201075013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"INSERM CNRS UM75 U1127 UMR 7225 ICM UPMC Univ. 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