{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:01:40Z","timestamp":1791198100149,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001866","name":"Fond National de la Recherche du Luxembourg","doi-asserted-by":"crossref","award":["PHD-09-111"],"award-info":[{"award-number":["PHD-09-111"]}],"id":[{"id":"10.13039\/501100001866","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corticosterone (<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic\u2013pituitary\u2013adrenal axis. Circulating <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> can enter the central nervous system and be reduced to neuroactive 3\u03b15\u03b1\u2010reduced steroids, which modulate GABA<jats:sub>A<\/jats:sub> receptors. In the dorsal spinal cord, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>ergic transmission modulates integration of nociceptive information. It has been shown that enhancing spinal inhibitory transmission alleviates hyperalgesia and allodynia. Therefore, the spinal neuronal network is a pivotal target to counteract pain symptoms. Thus, any increase in spinal 3\u03b15\u03b1\u2010reduced steroid production enhancing <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>ergic inhibition should reduce nociceptive message integration and the pain response. Previously, it has been shown that high levels of plasma glucocorticoids give rise to analgesia. However, to our knowledge, nothing has been reported regarding direct non\u2010genomic modulation of neuronal spinal activity by peripheral <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>. In the present study, we used combined <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> electrophysiology approaches, associated with measurement of nociceptive mechanical sensitivity and plasma <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> level measurement, to assess the impact of circulating <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> on rat nociception. We showed that <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> plasma level elevation produced analgesia via a reduction in C\u2010fiber\u2010mediated spinal responses. In the spine, <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> is reduced to the neuroactive metabolite allotetrahydrodeoxycorticosterone, which specifically enhances lamina <jats:styled-content style=\"fixed-case\">II GABA<\/jats:styled-content>ergic synaptic transmission. The main consequence is a reduction in lamina <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> network excitability, reflecting a selective decrease in the processing of nociceptive inputs. The depressed neuronal activity at the spinal level then, in turn, leads to weaker nociceptive message transmission to supraspinal structures and hence to alleviation of pain.<\/jats:p>","DOI":"10.1111\/ejn.12796","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T04:58:44Z","timestamp":1417064324000},"page":"390-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance <scp>GABA<\/scp>ergic inhibitory transmission on dorsal horn rat neurons"],"prefix":"10.1111","volume":"41","author":[{"given":"Vivien","family":"Zell","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique and University of Strasbourg Institut des Neurosciences Cellulaires et Int\u00e9gratives 5 rue Blaise Pascal F\u201067084 Strasbourg France"},{"name":"Laboratory of Neurophysiology 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