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Here, we addressed how neurosteroids modulate the occurrence of these interictal events and of the associated high\u2010frequency oscillations (<jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s) (ripples, 80\u2013200\u00a0Hz; fast ripples, 250\u2013500\u00a0Hz). Under control conditions (i.e. during 4<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>application), ripples and fast ripples were detected in 12.3 and 17.5% of fast events, respectively; in contrast, the majority of slow events (&gt;\u00a098%) did not co\u2010occur with<jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s. Application of 0.1, 1 or 5\u00a0\u03bc<jats:sc>m<\/jats:sc>allotetrahydrodeoxycorticosterone (<jats:styled-content style=\"fixed-case\">THDOC<\/jats:styled-content>) to 4<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010treated slices caused a dose\u2010dependent decrease in the duration of the fast events and an increase in the occurrence of ripples, but not fast ripples; in contrast, the duration of slow events increased.<jats:styled-content style=\"fixed-case\">THDOC<\/jats:styled-content>potentiated the slow events that were recorded during pharmacological blockade of glutamatergic transmission, but had no effect on interictal discharges occurring during<jats:styled-content style=\"fixed-case\">GABA<jats:sub>A<\/jats:sub><\/jats:styled-content>receptor antagonism. These results demonstrate that potentiation of<jats:styled-content style=\"fixed-case\">GABA<jats:sub>A<\/jats:sub><\/jats:styled-content>receptor\u2010mediated signaling by<jats:styled-content style=\"fixed-case\">THDOC<\/jats:styled-content>differentially affects slow and fast interictal discharges; these differences may provide insights into how hyperexcitable activity is influenced by neurosteroids.<\/jats:p>","DOI":"10.1111\/ejn.12797","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T13:36:22Z","timestamp":1417786582000},"page":"379-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal<scp>CA<\/scp>3 area"],"prefix":"10.1111","volume":"41","author":[{"given":"Rochelle","family":"Herrington","sequence":"first","affiliation":[{"name":"Department of Neurology &amp; Neurosurgery Montreal Neurological Institute McGill University Montr\u00e9al QC H3A 2B4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"L\u00e9vesque","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Neurosurgery Montreal Neurological Institute McGill University Montr\u00e9al QC H3A 2B4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Avoli","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Neurosurgery Montreal Neurological Institute McGill University Montr\u00e9al QC H3A 2B4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1073\/pnas.0606544103"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/0006-8993(94)91403-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/j.pneurobio.2011.07.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1523\/JNEUROSCI.16-12-03912.1996"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1016\/S0301-0082(02)00077-1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1016\/j.brainresrev.2006.01.007"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/0960-0760(90)90490-C"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1016\/j.clinph.2009.10.019"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1111\/j.1528-1167.2010.02896.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1016\/S0006-8993(99)02348-3"},{"volume-title":"Rhythms of the Brain","year":"2009","author":"Buzsaki G.","key":"e_1_2_7_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1126\/science.1589772"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1002\/ana.22610"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1016\/j.pneurobio.2012.02.001"},{"key":"e_1_2_7_16_1","first-page":"97","article-title":"Neurobiological evidence for epilepsy\u2010induced interictal disturbances","volume":"55","author":"Engel J.","year":"1990","journal-title":"Adv. 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