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A single direct <jats:italic>in vivo<\/jats:italic> application of Reelin enhances long\u2010term potentiation, increases dendritic spine density and improves associative and spatial learning and memory. Angelman syndrome (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) is a neurological disorder that presents with an overall defect in synaptic function, including decreased long\u2010term potentiation, reduced dendritic spine density, and deficits in learning and memory, making it an attractive model in which to examine the ability of Reelin to recover synaptic function and cognitive deficits. In this study, we investigated the effects of Reelin administration on synaptic plasticity and cognitive function in a mouse model of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and demonstrated that bilateral, intraventricular injections of Reelin recover synaptic function and corresponding hippocampus\u2010dependent associative and spatial learning and memory. Additionally, we describe alteration of the Reelin profile in tissue from both the <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> mouse and post\u2010mortem human brain.<\/jats:p>","DOI":"10.1111\/ejn.12893","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T07:15:11Z","timestamp":1428909311000},"page":"1372-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Whitney R.","family":"Hethorn","sequence":"first","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-3167","authenticated-orcid":false,"given":"Stephanie L.","family":"Ciarlone","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Filonova","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Rogers","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel A.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Grieco","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M.","family":"Peters","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Gulick","sequence":"additional","affiliation":[{"name":"USF Health Byrd Alzheimer's Institute 4001 East Fletcher Avenue Tampa FL 33613 USA"},{"name":"Department of Molecular Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"L. 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