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One of them, <jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>4, is reported to participate in aspects of neuronal development, such as axonal guidance and dendritic development. However, no physiological or behavioral phenotypes in <jats:italic>Crmp4<\/jats:italic> knockout (<jats:italic>Crmp4<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) mice have been identified, making it difficult to elucidate the <jats:italic>in\u00a0vivo<\/jats:italic> roles of <jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>4. Focusing on the olfaction process because of the previous study showing strong expression of <jats:italic>Crmp4 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in the olfactory bulb (<jats:styled-content style=\"fixed-case\">OB<\/jats:styled-content>) during the early postnatal period, it was aimed to test the hypothesis that <jats:italic>Crmp4<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> pups would exhibit abnormal olfaction. Based on measurements of their ultrasonic vocalizations, impaired olfactory ability in <jats:italic>Crmp4<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> pups was found. In addition, c\u2010Fos expression, a marker of neuron activity, revealed hyperactivity in the <jats:styled-content style=\"fixed-case\">OB<\/jats:styled-content> of <jats:italic>Crmp4<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> pups compared with wild\u2010types following exposure to an odorant. Moreover, the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expression levels of glutamate receptor 1 (GluR1) and 2 (GluR2) were exaggerated in <jats:italic>Crmp4<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> pups relative to other excitatory and inhibitory receptors and transporters, raising the possibility that enhanced expression of these excitatory receptors contributes to the hyperactivity phenotype and impairs olfactory ability. This study provides evidence for an animal model for elucidating the roles of <jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>4 in the development of higher brain functions as well as for elucidating the developmental regulatory mechanisms controlling the activity of the neural circuitry.<\/jats:p>","DOI":"10.1111\/ejn.12999","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T08:05:34Z","timestamp":1435219534000},"page":"2335-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb"],"prefix":"10.1111","volume":"42","author":[{"given":"Atsuhiro","family":"Tsutiya","sequence":"first","affiliation":[{"name":"Graduate School of Life Sciences Toyo University 1\u20101\u20101 Itakura Oura Gunma 374\u20100193 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