{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:30Z","timestamp":1790665590988,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brazil"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dopaminergic neurotransmission in the nucleus accumbens, a central component of the mesolimbic system, has been associated with acute pain modulation. As there is a transition from acute to chronic pain (\u2018chronification\u2019), modulatory structures may be involved in chronic pain development. Thus, this study aimed to elucidate the role of nucleus accumbens dopaminergic neurotransmission in chronification of pain. We used a rat model in which daily subcutaneous injection of prostaglandin E<jats:sub>2<\/jats:sub>in the hindpaw for 14\u00a0days induces a long\u2010lasting state of nociceptor sensitization that lasts for at least 30\u00a0days following the end of the treatment. Our findings demonstrated that the increase of dopamine in the nucleus accumbens by local administration of<jats:styled-content style=\"fixed-case\">GBR<\/jats:styled-content>12909 (0.5\u00a0nmol\/0.25\u00a0\u03bcL), a dopamine reuptake inhibitor, blocked prostaglandin E<jats:sub>2<\/jats:sub>\u2010induced acute hyperalgesia. This blockade was prevented by a dopamine D2 receptor antagonist (raclopride, 10\u00a0nmol\/0.25\u00a0\u03bcL) but not changed by a D1 receptor antagonist (<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>23390, 0.5, 3 or 10\u00a0nmol\/0.25\u00a0\u03bcL), both co\u2010administered with<jats:styled-content style=\"fixed-case\">GBR<\/jats:styled-content>12909 in the nucleus accumbens. In contrast, the induction of persistent hyperalgesia was facilitated by continuous infusion of<jats:styled-content style=\"fixed-case\">GBR<\/jats:styled-content>12909 in the nucleus accumbens (0.021\u00a0nmol\/0.5\u00a0\u03bcL\/h) over 7\u00a0days of prostaglandin E<jats:sub>2<\/jats:sub>treatment. The development of persistent hyperalgesia was impaired by<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>23390 (0.125\u00a0nmol\/0.5\u00a0\u03bcL\/h) and raclopride (0.416\u00a0nmol\/0.5\u00a0\u03bcL\/h), both administered continuously in the nucleus accumbens over 7\u00a0days. Taken together, our data suggest that the chronification of pain involves the plasticity of dopaminergic neurotransmission in the nucleus accumbens, which switches its modulatory role from antinociceptive to pronociceptive.<\/jats:p>","DOI":"10.1111\/ejn.13015","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:46:25Z","timestamp":1436899585000},"page":"2380-2389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nucleus accumbens dopaminergic neurotransmission switches its modulatory action in chronification of inflammatory hyperalgesia"],"prefix":"10.1111","volume":"42","author":[{"given":"Elayne Vieira","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar Renato","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Ramos","family":"Mari\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Schwambach","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Calili","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina Pedro","family":"Athie","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Oreste","family":"Pagliusi","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Herrera","family":"Tambeli","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Amilcar","family":"Parada","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology State University of Campinas Rua Monteiro Lobato 255, Cidade Universitaria Zeferino Vaz Box\u00a06109 13083\u2010865 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-3565(24)37364-1","article-title":"Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine","volume":"285","author":"Altier N.","year":"1998","journal-title":"J. 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