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We examined the effects of neurexin\u20101 perturbation on sleep in <jats:italic>Drosophila<\/jats:italic>, showing that neurexin\u20101 nulls displayed fragmented sleep and altered circadian rhythm. Conversely, the over\u2010expression of neurexin\u20101 could increase and consolidate night\u2010time sleep. This was not solely due to developmental effects as it could be induced acutely in adulthood, and was coupled with evidence of synaptic growth. The timing of over\u2010expression could differentially impact sleep patterns, with specific night\u2010time effects. These results show that neurexin\u20101 was dynamically involved in synaptic plasticity and sleep in <jats:italic>Drosophila<\/jats:italic>. Neurexin\u20101 and a number of its binding partners have been repeatedly associated with mental health disorders, including autism spectrum disorders, schizophrenia and Tourette syndrome, all of which are also linked to altered sleep patterns. How and when plasticity\u2010related proteins such as neurexin\u20101 function during sleep can provide vital information on the interaction between synaptic homeostasis and sleep, paving the way for more informed treatments of human disorders.<\/jats:p>","DOI":"10.1111\/ejn.13023","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T15:35:09Z","timestamp":1437492909000},"page":"2455-2466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neurexin\u20101 regulates sleep and synaptic plasticity in\u00a0<i>Drosophila melanogaster<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Aoife","family":"Larkin","sequence":"first","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Kirszenblat","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"van Swinderen","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Claudianos","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld 4072 Australia"},{"name":"School of Psychological Sciences Faculty of Biomedical and Psychological Sciences Monash University Melbourne Vic. 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