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The presence of diverse subsets of candidate genes in each individual with an<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>and the vast variability of phenotypical differences suggest that the interference of an exogenous environmental component may greatly contribute to the development of<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s. The lipid mediator prostaglandin E2 (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub>) is released from phospholipids of cell membranes, and is important in brain development and function;<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub>is involved in differentiation, synaptic plasticity and calcium regulation. The previous review already described extrinsic factors, including deficient dietary supplementation, and exposure to oxidative stress, infections and inflammation that can disrupt signaling of the<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub>pathway and contribute to<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s. In this review, the structure and establishment of two key protective barriers for the brain during early development are described: the blood\u2013brain barrier; and the placental barrier. Then, the first comprehensive summary of other environmental factors, such as exposure to chemicals in air pollution, pesticides and consumer products, which can also disturb<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub>signaling and increase the risk for developing<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s is provided. Also, how these exogenous agents are capable of crossing the protective barriers of the brain during critical developmental periods when barrier components are still\u00a0\u00a0being formed is described. This review underlines the importance of avoiding or limiting exposure to these factors during vulnerable periods in development.<\/jats:p>","DOI":"10.1111\/ejn.13028","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T10:29:22Z","timestamp":1438079362000},"page":"2742-2760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders"],"prefix":"10.1111","volume":"42","author":[{"given":"Christine T.","family":"Wong","sequence":"first","affiliation":[{"name":"School of Kinesiology and Health Science York University Toronto ON Canada M3J 1P3"},{"name":"Neuroscience Graduate Diploma Program York University Toronto ON Canada M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Wais","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science York University Toronto ON Canada M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota A.","family":"Crawford","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science York University Toronto ON Canada M3J 1P3"},{"name":"Neuroscience Graduate Diploma Program York University Toronto ON Canada M3J 1P3"},{"name":"Department of Biology York University Toronto ON Canada M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00064.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_5_5_1","first-page":"RA141","article-title":"Pesticides and oxidative stress: a review","volume":"10","author":"Abdollahi M.","year":"2004","journal-title":"Med. 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