{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:18:26Z","timestamp":1763201906448},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T00:00:00Z","timestamp":1440201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF\u20102011\u20100022529"],"award-info":[{"award-number":["NRF\u20102011\u20100022529"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histamine, a neurotransmitter\/neuromodulator implicated in the control of arousal state, exerts a potent phase\u2010shifting effect on the circadian clock in the rodent suprachiasmatic nucleus (<jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>). In this study, the mechanisms by which histamine resets the circadian clock in the mouse <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> were investigated. As a first step, Ca<jats:sup>2+<\/jats:sup>\u2010imaging techniques were used to demonstrate that histamine increases intracellular Ca<jats:sup>2+<\/jats:sup> concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>) in acutely dissociated <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> neurons and that this increase is blocked by the H1 histamine receptor (H1R) antagonist pyrilamine, the removal of extracellular Ca<jats:sup>2+<\/jats:sup> and the L\u2010type Ca<jats:sup>2+<\/jats:sup> channel blocker nimodipine. The histamine\u2010induced Ca<jats:sup>2+<\/jats:sup> transient is reduced, but not blocked, by application of the ryanodine receptor (RyR) blocker dantrolene. Immunohistochemical techniques indicated that Ca<jats:sub>V<\/jats:sub>1.3\u00a0L\u2010type Ca<jats:sup>2+<\/jats:sup> channels are expressed mainly in the somata of <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> cells along with the H1R, whereas Ca<jats:sub>V<\/jats:sub>1.2 channels are located primarily in the processes. Finally, extracellular single\u2010unit recordings demonstrated that the histamine\u2010elicited phase delay of the circadian neural activity rhythm recorded from <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> slices is blocked by pyrilamine, nimodipine and the knockout of Ca<jats:sub>V<\/jats:sub>1.3 channel. Again, application of dantrolene reduced but did not block the histamine\u2010induced phase delays. Collectively, these results indicate that, to reset the circadian clock, histamine increases [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> neurons by activating Ca<jats:sub>V<\/jats:sub>1.3 channels through H1R, and secondarily by causing Ca<jats:sup>2+<\/jats:sup>\u2010induced Ca<jats:sup>2+<\/jats:sup> release from RyR\u2010mediated internal stores.<\/jats:p>","DOI":"10.1111\/ejn.13030","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T10:28:50Z","timestamp":1438079330000},"page":"2467-2477","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Histamine resets the circadian clock in the suprachiasmatic nucleus through the H1R\u2010Ca<sub>V<\/sub>1.3\u2010RyR pathway in the mouse"],"prefix":"10.1111","volume":"42","author":[{"given":"Yoon Sik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Center for Functional Connectomics Korea Institute of Science and Technology Seoul 136\u2010791 Korea"},{"name":"Department of Nanobiomedical Science Dankook University Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuck\u2010Wah","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Bik MD9 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u2010Chul","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Colwell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences University of California\u2010Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Justin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Center for Functional Connectomics Korea Institute of Science and Technology Seoul 136\u2010791 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Institute Korea University College of Medicine Seoul 136\u2010705 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.02.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05679.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.01.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f884b1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-009-9102-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05286.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0804"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/382719a0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13468"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90465-Y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199902250-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7527589"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/28639"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00013-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00635-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0576-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1034"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00111-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411797200"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2215"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/16711"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00164-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90125-N"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90156-N"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.533bg.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/325529a0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03950.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00373-Q"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.170134"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90231-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12515.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-005-0001-x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730409333354"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873098129000129"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04387.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.12.003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2733-05.2005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0275-09.2009"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01023.2004"},{"key":"e_1_2_7_44_1","first-page":"S626","article-title":"PKA activation regulates L\u2010type Cav1.3 calcium channel in\u00a0vivo","volume":"120","author":"Ramadan O.","year":"2009","journal-title":"Circulation"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1740-3391-4-2"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01239-0"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2093-06.2006"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4643-06.2007"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021607"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90400-N"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90811-4"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135919"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-05944.2001"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.06.014"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00337.2007"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:24:58Z","timestamp":1696335898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13030"}},"subtitle":[],"editor":[{"given":"Rae","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,22]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/ejn.13030"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13030","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,22]]},"assertion":[{"value":"2015-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}