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Here, we used these reagents to show that these oligomeric \u03b1\u2010synuclein variants are preferentially present in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> brain tissue, <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> and serum, and that the oligomeric \u03b2\u2010amyloid variants are preferentially present in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> brain tissue, <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>, and serum. Some <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> samples also had \u03b1\u2010synuclein pathology and some <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> samples also had \u03b2\u2010amyloid pathology, and, very intriguingly, these <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> cases also had a history of dementia. Detection of different oligomeric \u03b1\u2010synuclein and \u03b2\u2010amyloid species is an effective method for identifying tissue, <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> and sera from <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> samples, respectively, and samples that also contained early stages of other protein pathologies, indicating their potential value as blood\u2010based biomarkers for neurodegenerative diseases.<\/jats:p>","DOI":"10.1111\/ejn.13056","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T16:07:40Z","timestamp":1441210060000},"page":"3-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Oligomeric \u03b1\u2010synuclein and \u03b2\u2010amyloid variants as potential biomarkers for Parkinson's and Alzheimer's 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