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To test the hypothesis that urocortins are stress hormones that are sufficient to enhance tactile and musculoskeletal hyperalgesia, von Frey fibre sensitivity and grip force after injection of corticotropin\u2010releasing factor (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>), urocortin I and urocortin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>were measured in mice. Urocortin I (a<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>2 receptor ligand) produced hyperalgesia in both assays when injected intrathecally (i.t.) but not intracerebroventricularly, and only at a large dose when injected peripherally, suggesting a spinal action. Morphine inhibited urocortin I\u2010induced changes in nociceptive responses in a dose\u2010related fashion, confirming that changes in behaviour reflect hyperalgesia rather than weakness. No tolerance developed to the effect of urocortin I (i.t.) when injected repeatedly, consistent with a potential to enhance pain chronically. Tactile hyperalgesia was inhibited by<jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content>\u201035965, a<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>1 receptor antagonist, but not astressin 2B, a<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>2 receptor antagonist. However, while urocortin I\u2010induced decreases in grip force were not observed when co\u2010administered i.t. with either<jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content>\u201035965 or astressin 2B, they were even more sensitive to inhibition by astressin, a non\u2010selective<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>receptor antagonist. Together these data indicate that urocortin I acts at<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>receptors in the mouse spinal cord to elicit a reproducible and persistent tactile (von Frey) and musculoskeletal (grip force) hyperalgesia. Urocortin I\u2010induced hyperalgesia may serve as a screen for drugs that alleviate painful conditions that are exacerbated by stress.<\/jats:p>","DOI":"10.1111\/ejn.13060","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T15:46:12Z","timestamp":1441208772000},"page":"2772-2782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intrathecal urocortin I in the spinal cord as a murine model of stress hormone\u2010induced musculoskeletal and tactile hyperalgesia"],"prefix":"10.1111","volume":"42","author":[{"given":"Alice A.","family":"Larson","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences University of Minnesota 1988 Fitch Avenue Room 295 St Paul MN 55108 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myra G.","family":"Nunez","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences University of Minnesota 1988 Fitch Avenue Room 295 St Paul MN 55108 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey L.","family":"Kissel","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences University of Minnesota 1988 Fitch Avenue Room 295 St Paul MN 55108 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin J.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences University of Minnesota 1988 Fitch Avenue Room 295 St Paul MN 55108 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80332-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91667-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01146.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991220)415:3<285::AID-CNE1>3.0.CO;2-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00199-0"},{"key":"e_1_2_6_8_1","first-page":"1167","article-title":"Fibromyalgia in inflammatory bowel disease","volume":"26","author":"Buskila D.","year":"1999","journal-title":"J. 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