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Transcranial direct current stimulation (<jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>) can be used to investigate how modulating cortical excitability affects performance of these tasks. This study investigated the effect of bi\u2010parietal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> on numerical processing, spatial and sustained attention. It was hypothesized that <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> would have distinct effects on these tasks because of varying lateralization (numerical processing left, spatial attention right) and that these effects are partly mediated by modulation of sustained attention. A single\u2010blinded, crossover, sham\u2010controlled study was performed. Eighteen healthy right\u2010handed participants performed cognitive tasks during three sessions of oppositional parietal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> stimulation: sham; right anodal with left cathodal (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>); and right cathodal with left anodal (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>). Participants performed a number comparison task, a modified Posner task, a choice reaction task (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) and the rapid visual processing task (<jats:styled-content style=\"fixed-case\">RVP<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LC tDCS<\/jats:styled-content> impaired number comparison performance compared with sham, with slower responses to numerically close numbers pairs. <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LA tDCS<\/jats:styled-content> had distinct effects on <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> performance, specifically affecting vigilance level during the final block of the task. No effect of stimulation on the Posner task or <jats:styled-content style=\"fixed-case\">RVP<\/jats:styled-content> was found. It was demonstrated that oppositional parietal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> affected both numerical performance and vigilance level in a polarity\u2010dependent manner. The effect of <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> on numerical processing may partly be due to attentional effects. The behavioural effects of <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> were specifically observed under high task demands, demonstrating the consequences of an interaction between stimulation type and cognitive load.<\/jats:p>","DOI":"10.1111\/ejn.13086","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T23:38:56Z","timestamp":1443483536000},"page":"2904-2914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions"],"prefix":"10.1111","volume":"42","author":[{"given":"Lucia M.","family":"Li","sequence":"first","affiliation":[{"name":"Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL) Division of Brain Sciences Department of Medicine Imperial College London C3NL 3rd Floor Burlington Danes Building Du Cane Road Fulham London W12 0NN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Leech","sequence":"additional","affiliation":[{"name":"Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL) Division of Brain Sciences Department of Medicine Imperial College London C3NL 3rd Floor Burlington Danes Building Du Cane Road Fulham London W12 0NN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Scott","sequence":"additional","affiliation":[{"name":"Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL) Division of Brain Sciences Department of Medicine Imperial College London C3NL 3rd Floor Burlington Danes Building Du Cane Road Fulham London W12 0NN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Centre for Restorative Neuroscience Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Seemungal","sequence":"additional","affiliation":[{"name":"Neuro\u2010Otology Unit Division of Brain Sciences Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL) Division of Brain Sciences Department of Medicine Imperial College London C3NL 3rd Floor Burlington Danes Building Du Cane Road Fulham London W12 0NN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172912.07640.92"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.06.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2013.06.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.10.083"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-6-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.04.016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24909"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.05.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.087"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.094417"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.062"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.10.026"},{"key":"e_1_2_6_14_1","first-page":"123","article-title":"Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients","volume":"25","author":"Boggio P.S.","year":"2007","journal-title":"Restor. 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