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There is increasing evidence that the Rho\/\n                    <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>\n                    (Rho kinase) signalling pathway may play a critical role in the inflammatory response, and\n                    <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>\n                    inhibitor has been reported to have neuroprotective effects. In this study, we examined the neuroprotective potential and possible mechanism of\n                    <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>\n                    inhibitor Fasudil in an intranasal lipopolysaccharide (\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    )\u2010induced\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    model.\n                    <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>\n                    was activated with\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    stimulation and inhibited by Fasudil treatment in this\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    model. Behavioural tests demonstrated a clear improvement in motor performance after Fasudil treatment. Furthermore, Fasudil resulted in a significant attenuation of dopamine cell loss, \u03b1\u2010synuclein accumulation and inflammatory response with the reversion of inflammatory M1 to anti\u2010inflammatory M2 microglia, decreased\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u043aB activation, and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201012 and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1 generation in the\n                    <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>\n                    and olfactory bulb in this model. This study establishes a role for Fasudil in protecting against\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    \u2010mediated dopamine degeneration and provides a therapeutic strategy for the treatment of\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/ejn.13132","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T11:22:42Z","timestamp":1447413762000},"page":"41-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["RETRACTED: Inhibition of Rho\u2010kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide\u2010mediated Parkinson's 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