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The current study aimed to make use of prior knowledge of sulcal anatomy and resting\u2010state functional connectivity, together with a novel visualization technique, to manually parcellate areas 44 and 45 in individual brains <jats:italic>in\u00a0vivo<\/jats:italic>. One hundred and one resting\u2010state functional magnetic resonance imaging datasets from the Human Connectome Project were used. Left\u2010hemisphere surface\u2010based correlation matrices were computed and visualized in brainGL. By observation of differences in the connectivity patterns of neighbouring nodes, areas 44 and 45 were manually parcellated in individual brains, and then compared at the group\u2010level. Additionally, the manual labelling approach was compared with parcellation results based on several data\u2010driven clustering techniques. Areas 44 and 45 could be clearly distinguished from each other in all individuals, and the manual segmentation method showed high test\u2010retest reliability. Group\u2010level probability maps of areas 44 and 45 showed spatial consistency across individuals, and corresponded well to cytoarchitectonic probability maps. Group\u2010level connectivity maps were consistent with previous studies showing distinct connectivity patterns of areas 44 and 45. Data\u2010driven parcellation techniques produced clusters with varying degrees of spatial overlap with the manual labels, indicating the need for further investigation and validation of machine learning cortical segmentation approaches. The current study provides a reliable method for individual\u2010level cortical parcellation that could be applied to regions distinguishable by even the most subtle differences in patterns of functional connectivity.<\/jats:p>","DOI":"10.1111\/ejn.13140","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T20:23:41Z","timestamp":1448655821000},"page":"561-571","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Subdivision of Broca's region based on individual\u2010level functional connectivity"],"prefix":"10.1111","volume":"43","author":[{"given":"Estrid","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Stephanstrasse 1A 04103 Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"B\u00f6ttger","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Stephanstrasse 1A 04103 Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bellec","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'institut de G\u00e9riatrie de Montr\u00e9al Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Geyer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Stephanstrasse 1A 04103 Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"R\u00fcbsamen","sequence":"additional","affiliation":[{"name":"University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Petrides","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Margulies","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Stephanstrasse 1A 04103 Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<319::AID-CNE10>3.0.CO;2-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk034"},{"key":"e_1_2_7_4_1","unstructured":"Arthur D.&Vassilvitskii S.(2007)k\u2010means++: the advantages of careful seeding.Proceedings of the Eighteenth Annual ACM\u2010SIAM Symposium on Discrete Algorithms. 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