{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:09:43Z","timestamp":1790186983972,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001262","name":"National Parkinson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The primary aim of our study was to determine the extent of vestibular dysfunction in patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). Our secondary aim was to determine if vestibular dysfunction in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> is a risk factor for falling. The tertiary aim was to determine both the extent of vestibular dysfunction and if this dysfunction is a risk factor for falling in patients with atypical parkinsonism (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>). Twenty\u2010five healthy subjects, 30 <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients and 14 <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients were matched for age and gender in a case\u2010control study design. All subjects underwent clinical neurological and neurotological assessments, cervical and ocular vestibular evoked myogenic potentials (<jats:styled-content style=\"fixed-case\">VEMP<\/jats:styled-content>s), brainstem auditory evoked potentials (<jats:styled-content style=\"fixed-case\">BAEP<\/jats:styled-content>s), subjective visual vertical measurements, and videonystagmography with caloric and rotatory chair stimulation. Ninety per cent of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients (27 of 30) and all 14 <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients had signs of vestibular dysfunction on laboratory examinations. The evoked potential (<jats:styled-content style=\"fixed-case\">VEMP<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">BAEP<\/jats:styled-content>s) test results of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients showed significant prolongation of the p13, n1 and interpeak <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013V latencies on the symptomatic brainstem side (0.003\u00a0\u2264\u00a0 <jats:italic>P\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>0.019) compared with healthy subjects. Also, vestibular testing abnormalities were correlated with an increased risk for falling when fallers among <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients were compared with the non\u2010fallers (<jats:italic>P\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>0.001). To conclude, vestibular dysfunction on vestibular laboratory testing is highly prevalent in both <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients compared with healthy subjects, and is associated with an increased risk for falling.<\/jats:p>","DOI":"10.1111\/ejn.13253","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:10:08Z","timestamp":1460311808000},"page":"1636-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Neurovestibular analysis and falls in Parkinson's disease and atypical parkinsonism"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Venhovens","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology Canisius Wilhelmina Hospital Nijmegen the Netherlands"},{"name":"Department of Neurology and Clinical Neurophysiology Albert Schweitzer Hospital Albert Schweitzerplaats 25 PO Box\u00a0444 3300 AK Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Meulstee","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology Canisius Wilhelmina Hospital Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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