{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:48:51Z","timestamp":1788576531661,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T00:00:00Z","timestamp":1464998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014R1A2A1A11051520"],"award-info":[{"award-number":["2014R1A2A1A11051520"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>\n \n Huntington's disease (\n HD<\/jats:styled-content>\n ) is a hereditary neurodegenerative disorder caused by the aggregation of mutant Huntingtin (\n mH<\/jats:styled-content>\n tt). Adipose\u2010derived stem cells (\n ASC<\/jats:styled-content>\n s) have a potential for use in the treatment of incurable disorders, including\n HD<\/jats:styled-content>\n .\n ASC<\/jats:styled-content>\n s secrete various neurotrophic factors and microvesicles, and modulate hostile microenvironments affected by disease through paracrine mechanisms. Exosomes are small vesicles that transport nucleic acid and protein between cells. Here, we investigated the therapeutic role of exosomes from\n ASC<\/jats:styled-content>\n s (\n ASC<\/jats:styled-content>\n \u2010exo) using\n in\u00a0vitro<\/jats:italic>\n HD<\/jats:styled-content>\n model by examining pathological phenotypes of this model. Immunocytochemistry result showed that\n ASC<\/jats:styled-content>\n \u2010exo significantly decreases\n mH<\/jats:styled-content>\n tt aggregates in R6\/2 mice\u2010derived neuronal cells. Western blot result further confirmed the reduction in\n mH<\/jats:styled-content>\n tt aggregates level by\n ASC<\/jats:styled-content>\n \u2010exo treatment.\n ASC<\/jats:styled-content>\n \u2010exo up\u2010regulates\n PGC<\/jats:styled-content>\n \u20101, phospho\u2010\n CREB<\/jats:styled-content>\n and ameliorates abnormal apoptotic protein level in an\n in\u00a0vitro<\/jats:italic>\n HD<\/jats:styled-content>\n model. In addition, Mito\n SOX<\/jats:styled-content>\n Red,\n JC<\/jats:styled-content>\n \u20101 and cell viability assay showed that\n ASC<\/jats:styled-content>\n \u2010exo reduces mitochondrial dysfunction and cell apoptosis of\n in\u00a0vitro<\/jats:italic>\n HD<\/jats:styled-content>\n model. These findings suggest that\n ASC<\/jats:styled-content>\n \u2010exo has a therapeutic potential for treating\n HD<\/jats:styled-content>\n by modulating representative cellular phenotypes of HD.\n <\/jats:p>","DOI":"10.1111\/ejn.13275","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T02:22:58Z","timestamp":1463192578000},"page":"2114-2119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Exosomes from adipose\u2010derived stem cells ameliorate phenotype of Huntington's disease\n in vitro<\/i>\n model"],"prefix":"10.1111","volume":"44","author":[{"given":"Mijung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital 101 Daehak\u2010ro, Jongno\u2010gu 110744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine USF Health Byrd Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseok","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital 101 Daehak\u2010ro, Jongno\u2010gu 110744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital 101 Daehak\u2010ro, Jongno\u2010gu 110744 Seoul Korea"},{"name":"Protein Metabolism Medical Research Center College of Medicine Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2013.01.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3282f0dd1f"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.02.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80513-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6104-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176826"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059438"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16887"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1774-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.192138"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2006.09.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.1.213"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21788"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.643"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.5.161"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.04.129"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6100"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.06.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.023"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01604.x"},{"key":"e_1_2_6_23_1","first-page":"442","article-title":"Adipose\u2010derived stem and stromal cells for cell\u2010based therapy: current status of preclinical studies and clinical trials","volume":"12","author":"Mizuno H.","year":"2010","journal-title":"Curr. 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