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The identification of direct links between neuroimaging signals and corresponding genetic factors can reveal cellular\u2010level mechanisms behind the measured macroscopic signals and contribute to the use of imaging signals as probes of genetic function. To uncover possible genetic determinants of the most prominent brain signal oscillation, the parieto\u2010occipital 10\u2010Hz alpha rhythm, we measured spontaneous brain activity with magnetoencephalography in 210 healthy siblings while the subjects were resting, with eyes closed and open. The reactivity of the alpha rhythm was quantified from the difference spectra between the two conditions. We focused on three measures: peak frequency, peak amplitude and the width of the main spectral peak. In accordance with earlier electroencephalography studies, spectral peak amplitude was highly heritable (<jats:italic>h<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0&gt;\u00a00.75). Variance component\u2010based analysis of 28\u00a0000 single\u2010nucleotide polymorphism markers revealed linkage for both the width and the amplitude of the spectral peak. The strongest linkage was detected for the width of the spectral peak over the left parieto\u2010occipital cortex on chromosome 10 (<jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\u00a0=\u00a02.814, nominal <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.03). This genomic region contains several functionally plausible genes, including <jats:italic><jats:styled-content style=\"fixed-case\">GRID<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ATAD<\/jats:styled-content>1<\/jats:italic> that regulate glutamate receptor channels mediating synaptic transmission, <jats:italic><jats:styled-content style=\"fixed-case\">NRG<\/jats:styled-content>3<\/jats:italic> with functions in brain development and <jats:italic><jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content>7<\/jats:italic> involved in the serotonergic system and circadian rhythm. Our data suggest that the alpha oscillation is in part genetically regulated, and that it may be possible to identify its regulators by genetic analyses on a realistically modest number of samples.<\/jats:p>","DOI":"10.1111\/ejn.13300","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T08:39:06Z","timestamp":1466066346000},"page":"1963-1971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evidence for genetic regulation of the human parieto\u2010occipital 10\u2010Hz rhythmic activity"],"prefix":"10.1111","volume":"44","author":[{"given":"Elina","family":"Salmela","sequence":"first","affiliation":[{"name":"Molecular Neurology Research Program Research Programs Unit University of Helsinki PO Box\u00a063 FI\u201000014 Helsinki Finland"},{"name":"Folkh\u00e4lsan Institute of Genetics Biomedicum Helsinki Helsinki 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