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This unique connectivity suggests that the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content> plays a pivotal role in regulating information flow through the thalamus. Here, we analyzed the roles of <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content> neurons in visually guided reaching movements. We first used retrograde transneuronal labeling with rabies virus, and showed that the rostro\u2010dorsal sector of the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd) projected disynaptically to the ventral premotor cortex (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v). In other experiments, we recorded neurons from the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd or <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v while monkeys performed a visuomotor task. We found that neurons in the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd and <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v showed visual\u2010, set\u2010, and movement\u2010related activity modulation. These results indicate that the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd, as well as the <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v, is involved in the reception of visual signals and in the preparation and execution of reaching movements. The fraction of neurons that were non\u2010selective for the location of visual signals or the direction of reaching movements was greater in the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd than in the <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v. Furthermore, the fraction of neurons whose activity increased from the baseline was greater in the <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd than in the <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v. The timing of activity modulation of visual\u2010related and movement\u2010related neurons was similar in <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd and <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>v neurons. Overall, our data suggest that <jats:styled-content style=\"fixed-case\">TRN<\/jats:styled-content>rd neurons provide motor thalamic nuclei with inhibitory inputs that are predominantly devoid of spatial selectivity, and that these signals modulate how these nuclei engage in both sensory processing and motor output during visually guided reaching behavior.<\/jats:p>","DOI":"10.1111\/ejn.13421","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T19:10:27Z","timestamp":1476299427000},"page":"1186-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Visuomotor signals for reaching movements in the rostro\u2010dorsal sector of the monkey thalamic reticular nucleus"],"prefix":"10.1111","volume":"45","author":[{"given":"Yosuke","family":"Saga","sequence":"first","affiliation":[{"name":"Frontal Lobe Function Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Centre de Neuroscience Cognitive Marc Jeannerod UMR\u20105229 CNRS 67 Boulevard Pinel 69675 Bron Cedex France"},{"name":"Tamagawa University Brain Science Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Frontal Lobe Function Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Tamagawa University Brain Science Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Systems Neuroscience Section Primate Research Institute Kyoto University Inuyama Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Frontal Lobe Function Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Tamagawa University Brain Science Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Frontal Lobe Function Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Tamagawa University Brain Science Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Centre de Neuroscience Cognitive Marc Jeannerod UMR\u20105229 CNRS 67 Boulevard Pinel 69675 Bron Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Takada","sequence":"additional","affiliation":[{"name":"Systems Neuroscience Section Primate Research Institute Kyoto University Inuyama Aichi Japan"},{"name":"AMED\u2010CREST Japan Agency for Medical Research and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Frontal Lobe Function Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Tamagawa University Brain Science Institute Tokyo Japan"},{"name":"AMED\u2010CREST Japan Agency for Medical Research and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/372669a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3897"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.1.164"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.1.133"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227337"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229651"},{"key":"e_1_2_8_8_1","first-page":"587","article-title":"Cortical connexions of the thalamic reticular nucleus","volume":"98","author":"Carman J.B.","year":"1964","journal-title":"J. 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