{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:18:07Z","timestamp":1777547887155,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although previous studies have shown that patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) may exhibit impaired decision making (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>), the specific neuro\u2010cognitive processes that underlie this deficiency remain unknown. Inefficient <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> may occur due to poor option assessment or a deficit in the evaluation of choice outcomes. This study uses, for the first time, the event\u2010related potential (<jats:styled-content style=\"fixed-case\">ERP<\/jats:styled-content>) technique to analyze these <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> subprocesses in patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Sixteen <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients and nineteen control subjects performed a <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> task based on the Iowa Gambling Task while a digital <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> was recorded. The P3b was analyzed as an index of option assessment, and both the feedback\u2010related negativity (<jats:styled-content style=\"fixed-case\">FRN<\/jats:styled-content>) and P3b were considered markers for choice outcome evaluation. We found that <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients made a larger number of unfavorable choices during the <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> task (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), with no differences between groups for reaction times. There were no significant differences in P3b for option assessment between the groups. In the control group, the type of feedback (gain, loss, or nothing) modified the <jats:styled-content style=\"fixed-case\">FRN<\/jats:styled-content> (<jats:italic>F<\/jats:italic>\u00a0=\u00a03.72, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.033) and the P3b (<jats:italic>F<\/jats:italic>\u00a0=\u00a03.15, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.059). This effect was not observed in the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group. Also, <jats:styled-content style=\"fixed-case\">FRN<\/jats:styled-content> latencies were shorter in the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047). Finally, lesions in temporal regions revealed by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> were associated with <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> both in behavioral and electrophysiological terms. We conclude that the <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> impairment of patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> may be due to a deficit in their evaluation of choice outcomes or a general alteration in emotional reactivity.<\/jats:p>","DOI":"10.1111\/ejn.13465","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T14:59:27Z","timestamp":1478357967000},"page":"321-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Electrophysiological correlates of decision making impairment in multiple sclerosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Elisa","family":"Azc\u00e1rraga\u2010Guirola","sequence":"first","affiliation":[{"name":"Neuropsychology Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez (INNNMVS) Insurgentes Sur 3877, Col. La Fama, Tlalpan. C.P. 14269 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaneth","family":"Rodr\u00edguez\u2010Agudelo","sequence":"additional","affiliation":[{"name":"Neuropsychology Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez (INNNMVS) Insurgentes Sur 3877, Col. La Fama, Tlalpan. C.P. 14269 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Vel\u00e1zquez\u2010Cardoso","sequence":"additional","affiliation":[{"name":"Neuropsychology Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez (INNNMVS) Insurgentes Sur 3877, Col. La Fama, Tlalpan. C.P. 14269 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamel","family":"Rito\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Clinic INNNMVS Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Sol\u00eds\u2010Vivanco","sequence":"additional","affiliation":[{"name":"Neuropsychology Department Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez (INNNMVS) Insurgentes Sur 3877, Col. La Fama, Tlalpan. C.P. 14269 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.11.4.535"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2003.04.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(94)90018-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00428.1998"},{"key":"e_1_2_7_6_1","volume-title":"Beck Depression Inventory","author":"Beck A.","year":"1978"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1176\/jnp.13.1.70","article-title":"Personality disorder in multiple sclerosis correlates with cognitive impairment","volume":"13","author":"Benedict R.H.","year":"2001","journal-title":"J. Neuropsych. Clin. N."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00221309.1948.9918159"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.10.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.03.017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(03)00284-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(97)00023-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00041-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.08.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.04.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.11.1.51"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2007.09.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00278-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004918"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1176\/jnp.16.3.350","article-title":"Construct validity and frequency of euphoria sclerotica in multiple sclerosis","volume":"16","author":"Fishman I.","year":"2004","journal-title":"J. Neuropsych. Clin. N."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.15"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(98)00004-X"},{"key":"e_1_2_7_25_1","first-page":"445","article-title":"Disfunci\u00f3n orbitofrontal en la esclerosis m\u00faltiple: Iowa Gambling Task","volume":"20","author":"Garc\u00eda\u2010Molina A.","year":"2008","journal-title":"Psicothema"},{"key":"e_1_2_7_26_1","first-page":"94","article-title":"Evaluaci\u00f3n de la toma de decisiones en dos formas evolutivas de la esclerosis m\u00faltiple","volume":"24","author":"Garc\u00eda\u2010Molina A.","year":"2009","journal-title":"Neurologia"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2005.04.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.02.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk040"},{"key":"e_1_2_7_30_1","first-page":"371","article-title":"The ten\u2010twenty electrode system for the International Federation","volume":"10","author":"Jasper H.","year":"1958","journal-title":"Electroen. Clin. Neuro."},{"key":"e_1_2_7_31_1","first-page":"26","article-title":"La estandarizaci\u00f3n del Inventario de Depresi\u00f3n de Beck para los residentes de la Ciudad de M\u00e9xico","volume":"3","author":"Jurado S.","year":"1998","journal-title":"Salud Ment."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.08.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20277"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.7.934"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.08.014"},{"key":"e_1_2_7_37_1","volume-title":"Neuropsychological Assessment","author":"Lezak M.","year":"2004"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01446.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf049"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2008.10.019"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00678.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617706060644"},{"key":"e_1_2_7_45_1","first-page":"583","article-title":"Alteraciones cognitivas en etapas iniciales de la esclerosis m\u00faltiple y su relaci\u00f3n con el estado de \u00e1nimo, variables demogr\u00e1ficas y cl\u00ednicas","volume":"20","author":"Nieto\u2010Barco A.","year":"2008","journal-title":"Psicothema"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.4.510"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_2_7_48_1","first-page":"9","article-title":"Deterioro cognitivo en esclerosis m\u00faltiple","volume":"12","author":"Oreja C.","year":"2009","journal-title":"Rev. Esp. Escler. Mult."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513475490"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.01.001"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.019"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.039198"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084270"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1982.0082"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0025-5"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090262"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2009.00449.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610294001602"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/135245850000600406"},{"key":"e_1_2_7_60_1","volume-title":"Escala Wechsler de Inteligencia para Adultos (WAIS\u2010III)","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2411050792"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh153"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:20:35Z","timestamp":1696339235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13465"}},"subtitle":[],"editor":[{"given":"Sophie","family":"Molholm","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,25]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ejn.13465"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13465","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,25]]},"assertion":[{"value":"2016-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}