{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:38:42Z","timestamp":1777595922442,"version":"3.51.4"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000703","name":"Action on Hearing Loss","doi-asserted-by":"publisher","award":["G62"],"award-info":[{"award-number":["G62"]}],"id":[{"id":"10.13039\/501100000703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tinnitus chronically affects between 10\u201315% of the population but, despite its prevalence, the underlying mechanisms are still not properly understood. One experimental model involves administration of high doses of sodium salicylate, as this is known to reliably induce tinnitus in both humans and animals. Guinea pigs were implanted with chronic electrocorticography (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>oG) electrode arrays, with silver\u2010ball electrodes placed on the dura over left and right auditory cortex. Two more electrodes were positioned over the cerebellum to monitor auditory brainstem responses (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>s). We recorded resting\u2010state and auditory evoked neural activity from awake animals before and 2\u00a0h following salicylate administration (350\u00a0mg\/kg; i.p.). Large increases in click\u2010evoked responses (&gt;\u00a0100%) were evident across the whole auditory cortex, despite significant reductions in wave I <jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content> amplitudes (in response to 20\u00a0kHz tones), which are indicative of auditory nerve activity. In the same animals, significant decreases in 6\u201310\u00a0Hz spontaneous oscillations (alpha waves) were evident over dorsocaudal auditory cortex. We were also able to demonstrate for the first time that cortical evoked potentials can be inhibited by a preceding gap in background noise [gap\u2010induced pre\u2010pulse inhibition (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>)], in a similar fashion to the gap\u2010induced inhibition of the acoustic startle reflex that is used as a behavioural test for tinnitus. Furthermore, 2\u00a0h following salicylate administration, we observed significant deficits in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> of cortical responses that were closely aligned with significant deficits in behavioural responses to the same stimuli. Together, these data are suggestive of neural correlates of tinnitus and oversensitivity to sound (hyperacusis).<\/jats:p>","DOI":"10.1111\/ejn.13474","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T17:36:50Z","timestamp":1479145010000},"page":"398-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs"],"prefix":"10.1111","volume":"45","author":[{"given":"Joel I.","family":"Berger","sequence":"first","affiliation":[{"name":"MRC Institute of Hearing Research University Park Nottingham NG7 2RD UK"},{"name":"School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Coomber","sequence":"additional","affiliation":[{"name":"MRC Institute of Hearing Research University Park Nottingham NG7 2RD UK"},{"name":"School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark N.","family":"Wallace","sequence":"additional","affiliation":[{"name":"MRC Institute of Hearing Research University Park Nottingham NG7 2RD UK"},{"name":"School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"MRC Institute of Hearing Research University Park Nottingham NG7 2RD UK"},{"name":"School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22314"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.04.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-012-0340-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/010503999424653"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.08.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00206"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680309601203"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60142-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.12.023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00203"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000156"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463-1741.121232"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00027-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0375-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12580"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00124"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.077"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.01.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01242.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1836-x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.05.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00088"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051646"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4915-12.2013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.105.1.33"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-16-04881.1996"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.10.007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.08.002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jesp.2013.03.013"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15222"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895408"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.06.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0276-1"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117228"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.04.073"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.03.024"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00180-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367706778476370"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/608437"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.12.063"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.22.2.5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00031"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181de4662"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-2930(14)50006-2"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04774.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2156-11.2011"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/436146"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00028"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2013.07.021"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(90)90144-E"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.7874\/kja.2013.17.3.118"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.024"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283013d7e"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1044\/1059-0889(2008\/08-0006)"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.1.188"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22827"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.031"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020153"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.06.013"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.073"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:17:27Z","timestamp":1696364247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13474"}},"subtitle":[],"editor":[{"given":"John","family":"Foxe","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/ejn.13474"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13474","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"2016-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}