{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:59:57Z","timestamp":1784224797897,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Interdisciplinary Center for Clinical Research Erlangen"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine\u2010tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, \u03b3\u2010aminobutyric acid (<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>) and glycine, and is one of the first sites affected by synapto\u2010 and neuropathy in the development of hearing loss. While the functions of acetylcholine, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> and other inhibitory transmitters within these feedback loops are at least partially understood, especially the function of glycine still remains elusive. To address this question, we investigated hearing in glycine receptor (GlyR) \u03b13 knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) and wildtype (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) mice. We found no differences in pure tone hearing thresholds at 11.3 and 16\u00a0<jats:styled-content style=\"fixed-case\">kH<\/jats:styled-content>z between the two groups as assessed by auditory brainstem response (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>) measurements. Detailed analysis of the <jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content> waves at 11.3\u00a0<jats:styled-content style=\"fixed-case\">kH<\/jats:styled-content>z, however, revealed a latency decrease of wave <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and an amplitude increase of wave <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> animals. GlyR\u03b13 <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> animals showed significantly impaired prepulse inhibition of the auditory startle response in a noisy environment, indicating that GlyR\u03b13\u2010mediated glycinergic inhibition is important for signal\u2010in\u2010noise detection.<\/jats:p>","DOI":"10.1111\/ejn.13489","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T04:06:49Z","timestamp":1480306009000},"page":"581-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deficit in acoustic signal\u2010in\u2010noise detection in glycine receptor \u03b13 subunit knockout mice"],"prefix":"10.1111","volume":"45","author":[{"given":"Konstantin","family":"Tziridis","sequence":"first","affiliation":[{"name":"Experimental Otolaryngology ENT Hospital Erlangen Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Waldstrasse 1 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Buerbank","sequence":"additional","affiliation":[{"name":"Experimental Otolaryngology ENT Hospital Erlangen Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Waldstrasse 1 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Eulenburg","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Emil\u2010Fischer\u2010Zentrum Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dlugaiczyk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Saarland University Hospital Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Schulze","sequence":"additional","affiliation":[{"name":"Experimental Otolaryngology ENT Hospital Erlangen Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Waldstrasse 1 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0855-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(82)90054-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00955.2006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0387-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.05.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.408229"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.04.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1828"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00537.2003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000240507.83072.e7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32833e05d6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094925"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000191942.36672.f3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(79)90146-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0312-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.6.2519"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)02296-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.092"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00160-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04701.2000"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5027-12.2013"},{"key":"e_1_2_7_24_1","first-page":"1","article-title":"Perceptual consequences of \u201chidden\u201d hearing loss","volume":"18","author":"Plack C.J.","year":"2014","journal-title":"Trends Hear."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.08.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00127-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7070-1_4"},{"key":"e_1_2_7_28_1","first-page":"1","article-title":"Evaluation of the social and economic costs of hearing impairment","author":"Shield B.","year":"2006","journal-title":"Hear\u2010it AISBL"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.08.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00022"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4236\/oja.2012.21004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1987.57.4.1002"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.13489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:15:20Z","timestamp":1694369720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13489"}},"subtitle":[],"editor":[{"given":"James","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,18]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/ejn.13489"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13489","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,18]]},"assertion":[{"value":"2016-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}