{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:13Z","timestamp":1772160193937,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Maynooth University Research Ethics Committee","award":["BSRESC-2015-001"],"award-info":[{"award-number":["BSRESC-2015-001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Synaesthesia is a developmental condition involving cross\u2010communication between sensory modalities or substreams whereby an inducer (e.g. a sound) automatically evokes a concurrent percept in another modality (e.g. a colour). Whether this condition arises due to atypical structural connectivity (e.g., between normally unconnected cortical areas) or altered neurochemistry remains a central question. We report the exceptional cases of two synaesthetes \u2013 subjects\n                    <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    \u2013 both of whom experience coloured auras around individuals, as well as coloured perceptions in response to music. Both subjects have, in recent years, suffered a complete loss or reduction of their synaesthetic experiences, one (\n                    <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>\n                    ) through successive head traumas, including a lightning strike, followed by a number of medications, and the other (\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    ) while taking anxiolytic medications. Using semi\u2010structured interviews and data from the Synaesthesia Battery and a colourpicker task, we characterize the phenomenological characteristics of their pre\u2010loss synaesthesia, as well as the subsequent restoration of each subject's synaesthetic experiences (in the months post\u2010trauma for\n                    <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>\n                    , and after cessation of medication for\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    ). Even after years of suppression, the patterns of associations were highly consistent with those experienced pre\u2010injury. The phenomenological experience of synaesthesia can, thus, like most conscious experiences, be modulated by pharmacologically diverse medications or head injury. However, the underlying neural substrates mediating specific synaesthetic pairings appear remarkably \u2018hard\u2010wired\u2019 and can persist over very long periods even under conditions that alter or completely suppress the conscious synaesthetic experience itself.\n                  <\/jats:p>","DOI":"10.1111\/ejn.13492","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T11:06:30Z","timestamp":1480331190000},"page":"472-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synaesthesia lost and found: two cases of person\u2010 and music\u2010colour synaesthesia"],"prefix":"10.1111","volume":"45","author":[{"given":"Francesca R.","family":"Farina","sequence":"first","affiliation":[{"name":"School of Psychology University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-4530","authenticated-orcid":false,"given":"Kevin J.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience and Smurfit Institute of Genetics University of Dublin, Trinity College, Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A. 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