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Anorexia nervosa (AN) and bulimia nervosa (BN) have been largely studied with brain magnetic resonance imaging (MRI) in relation to the functional mechanisms of high\u2010level processing, but not in terms of possible inter\u2010hemispheric functional connectivity anomalies. Using resting\u2010state functional MRI (fMRI), voxel\u2010mirrored homotopic connectivity (VMHC) and regional inter\u2010hemispheric spectral coherence (IHSC) were studied in 15 AN and 13 BN patients and 16 healthy controls (HC). Using T1\u2010weighted and diffusion tensor imaging MRI scans, regional VMHC values were correlated with the left\u2010right asymmetry of corresponding homotopic gray matter volumes and with the white matter callosal fractional anisotropy (FA). Compared to HC, AN patients exhibited reduced VMHC in cerebellum, insula, and precuneus, while BN patients showed reduced VMHC in dorso\u2010lateral prefrontal and orbito\u2010frontal cortices. The regional IHSC analysis highlighted that the inter\u2010hemispheric functional connectivity was higher in the \u2018Slow\u20105\u2019 band in all regions except the insula. No group differences in left\u2013right structural asymmetries and in VMHC vs. callosal FA correlations were significant in the comparisons between cohorts. These anomalies, not explained by structural changes, indicate that AN and BN, at least in their acute phase, are associated with a loss of inter\u2010hemispheric connectivity in regions implicated in self\u2010referential, cognitive control and reward processing. These findings may thus gather novel functional markers to explore aberrant features of these eating disorders.<\/jats:p>","DOI":"10.1111\/ejn.13507","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T14:36:47Z","timestamp":1482158207000},"page":"1129-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Interhemispheric functional connectivity in anorexia and bulimia nervosa"],"prefix":"10.1111","volume":"45","author":[{"given":"Antonietta","family":"Canna","sequence":"first","affiliation":[{"name":"Section\u00a0of Neurosciences Department of Medicine, Surgery and Dentistry Scuola Medica Salernitana University of Salerno Via S. 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