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Mutant mice with a deletion of Reelin, its lipoprotein receptors, or its intracellular adaptor protein Disabled\u20101 (Dab1), exhibit nociceptive abnormalities: thermal (heat) hyperalgesia and reduced mechanical sensitivity. To determine dorsal horn alterations associated with these nociceptive abnormalities, we first characterized the correctly positioned Dab1 neurons in wild\u2010type and mispositioned neurons in Reelin\u2010signaling pathway mutant lumbar spinal cord. Using immunofluorescence, we found that 70% of the numerous Dab1 neurons in <jats:italic>Reln<\/jats:italic><jats:sup><jats:italic>+\/+<\/jats:italic><\/jats:sup> laminae I\u2013<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and 67% of those in the lateral reticulated area and lateral spinal nucleus (LSN) co\u2010express the <jats:styled-content style=\"fixed-case\">LIM<\/jats:styled-content>\u2010homeobox transcription factor 1 beta (Lmx1b), an excitatory glutamatergic neuron marker. Evidence of Dab1\u2010 and Dab1\u2010Lmx1b neuronal positioning errors was found within the isolectin B4 terminal region of <jats:italic>Reln<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> lamina <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>inner and in the lateral reticulated area and LSN, where about 50% of the Dab1\u2010Lmx1b neurons are missing. Importantly, Dab1\u2010Lmx1b neurons in laminae I\u2013<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and the lateral reticulated area express Fos after noxious thermal or mechanical stimulation and thus participate in these circuits. In another pain relevant locus \u2013 the lateral cervical nucleus (LCN), we also found about a 50% loss of Dab1\u2010Lmx1b neurons in <jats:italic>Reln<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice. We suggest that extensively mispositioned Dab1 projection neurons in the lateral reticulated area, LSN, and LCN and the more subtle positioning errors of Dab1 interneurons in laminae I\u2013<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> contribute to the abnormalities in pain responses found in Reelin\u2010signaling pathway mutants.<\/jats:p>","DOI":"10.1111\/ejn.13520","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:10:44Z","timestamp":1484320244000},"page":"733-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Disabled\u20101 dorsal horn spinal cord neurons co\u2010express Lmx1b and function in nociceptive circuits"],"prefix":"10.1111","volume":"45","author":[{"given":"Griselda M.","family":"Yvone","sequence":"first","affiliation":[{"name":"Department of Integrative Biology and Physiology UCLA Terasaki Life Sciences Building 610 Charles Young Dr. E 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