{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:27:01Z","timestamp":1791293221546,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010590","name":"Tianjin Health and Family Planning Commission","doi-asserted-by":"crossref","award":["15KG124"],"award-info":[{"award-number":["15KG124"]}],"id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the peripheral nervous system has an intrinsic ability for repair and regeneration after injury, bridging long peripheral nerve defects remains a challenge. Functional nerve regeneration depends on interactions among axons, Schwann cells, fibroblasts and immune cells. Macrophages, as immune cells recruited early in this process, show polarization toward phenotypes that are detrimental or beneficial to tissue remodeling depending on the microenvironment of the scaffolds. In this study, we investigated the effects of macrophage phenotypes modulated by collagen <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> on axonal regeneration and functional recovery by bridging a 15\u2010mm\u2010long sciatic nerve defect in rats. Our results showed that local delivery of collagen <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> within a polycaprolactone (<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>) electrospun conduit increased the recruitment of macrophages and their polarization toward the pro\u2010healing (M2) phenotype. In addition, the axonal regeneration and neurologic functional recovery in the <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>\/collagen <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> conduit group are equivalent to that of an autograft. In conclusion, the present study confirmed that <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>\/collagen <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> conduits with sustained release of collagen <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> in the local microenvironment may, through triggering macrophage M2 polarization to enhance the nerve regeneration, suggest that our combined biomaterial\u2010immunomodulatory system may be an attractive candidate for peripheral nerve regeneration.<\/jats:p>","DOI":"10.1111\/ejn.13558","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:34:52Z","timestamp":1488814492000},"page":"1258-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Sustained release of collagen <scp>VI<\/scp> potentiates sciatic nerve regeneration by modulating macrophage phenotype"],"prefix":"10.1111","volume":"45","author":[{"given":"Dan","family":"Lv","sequence":"first","affiliation":[{"name":"The graduate School Tianjin Medical University Tianjin China"},{"name":"Department of Orthopaedics Pingjin Hospital Logistics University of the Chinese People's Armed Police Forces Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province (Anhui) Stomatologic Hospital &amp; College Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province (Anhui) Stomatologic Hospital &amp; College Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-301X","authenticated-orcid":false,"given":"Yongcheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Tianjin Hospital Tianjin 300210 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.05.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.4.1163"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1369-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23612"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2240"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.03.057"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.050"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm300313h"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn401562f"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1797-14.2015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.04.026"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13054"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0386-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2183-y"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.022"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1924-15.2015"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201405166"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310022"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012079"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2015.0311"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23598"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.08.050"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13033"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216650293"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.005"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0364-y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.03.013"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.227"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.017"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2014.0606"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00303-3"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.078"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2219-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2298-1"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201600284"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejn.13558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.13558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:23:40Z","timestamp":1696368220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.13558"}},"subtitle":[],"editor":[{"given":"Deniz","family":"Kirik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,20]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/ejn.13558"],"URL":"https:\/\/doi.org\/10.1111\/ejn.13558","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,20]]},"assertion":[{"value":"2016-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}