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The rampant motoneuron death, inhibitory <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> transitional zone (<jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content>) for axonal regrowth and limited regeneration speed together lead to motor dysfunction. Microtubules rearrange to assemble a new growth cone and disorganized microtubules underline regeneration failure. It has been shown that microtubule\u2010stabilizing drug, Epothilone B, enhanced axonal regeneration and attenuated fibrotic scaring after spinal cord injury. Here, we are reporting that after spinal root avulsion+ re\u2010implantation in adult rats, EpoB treatment improved motor functional recovery and potentiated electrical responses of motor units. It facilitated axons to cross the <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content> and promoted more and bigger axons in the peripheral nerve. Neuromuscular junctions were reformed with better preserved postsynaptic structure, and muscle atrophy was prevented by EpoB administration. Our study showed that EpoB was a promising therapy for promoting axonal regeneration after peripheral nerve injury.<\/jats:p>","DOI":"10.1111\/ejn.13585","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T08:11:56Z","timestamp":1493194316000},"page":"1650-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Microtubule stabilization promoted axonal regeneration and functional recovery after spinal root avulsion"],"prefix":"10.1111","volume":"46","author":[{"given":"Heng","family":"Li","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences Li Ka Shing Faculty of Medicine the University of Hong Kong L1\u201039 21 Sassoon Road Pokfulam Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-4664","authenticated-orcid":false,"given":"Wutian","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Li Ka Shing Faculty of Medicine the University of Hong Kong L1\u201039 21 Sassoon Road Pokfulam Hong Kong SAR China"},{"name":"State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR China"},{"name":"Joint Laboratory of Jinan University and the University of Hong Kong GHM Institute of CNS Regeneration Jinan University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03670.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS132823"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0188-12.2012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(93)90068-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3176"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2015.02.006"},{"key":"e_1_2_10_8_1","volume-title":"Neuromuscular Function and Disease: Basic, Clinical, and Electrodiagnostic Aspects","author":"Brown W.F.","year":"2002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2959"},{"key":"e_1_2_10_10_1","volume-title":"Degeneration and Regeneration of the Nervous System","author":"Cajal R.Y.","year":"1928"},{"key":"e_1_2_10_11_1","first-page":"225","article-title":"Root repair review \u2013 Basic science background and clinical outcome","volume":"26","author":"Carlsedt T.","year":"2008","journal-title":"Restor. 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