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In humans, both children and adults with autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) present alterations in their estimation of time intervals. At present, there are no records of interval timing studies in animal models of<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. Hence, the objective of the present work was to evaluate interval timing in a mouse model of prenatal exposure to valproic acid (<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>) \u2013 a treatment used to induce human\u2010like autistic features in rodent models. Animals were assessed for their ability to acquire timing responses in 15\u2010s and 45\u2010s peak\u2010interval (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) procedures. Our results indicate that both female and male mice prenatally exposed to<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>present decreased timing accuracy and precision compared to control groups, as well as deviations from the scalar property. Moreover, the observed timing deficits in male<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>mice were reversed after early social enrichment. Furthermore, catecholamine determination by<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>indicated significant differences in striatal dopaminergic, but not serotonergic, content in female and male<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>mice, consistent with previously identified alterations in dopamine metabolism in<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. These deficits in temporal processing in a mouse model of autism complement previous results in humans, and provide a useful tool for further behavioral and pharmacological studies.<\/jats:p>","DOI":"10.1111\/ejn.13621","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T07:47:23Z","timestamp":1497426443000},"page":"619-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Deficits in temporal processing in mice prenatally exposed to Valproic Acid"],"prefix":"10.1111","volume":"47","author":[{"given":"Julieta","family":"Acosta","sequence":"first","affiliation":[{"name":"Laboratorio de Cronobiolog\u00eda Departamento de Ciencia y Tecnolog\u00eda Universidad Nacional de Quilmes\/CONICET Roque S\u00e1enz Pe\u00f1a 352 Bernal Buenos Aires B1876BXD Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A.","family":"Campolongo","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda Biolog\u00eda Molecular y Neurociencias CONICET\u2010UBA Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"H\u00f6cht","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda Facultad de Farmacia y Bioqu\u00edmica UBA Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaicha M.","family":"Depino","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda Biolog\u00eda Molecular y Neurociencias CONICET\u2010UBA Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Golombek","sequence":"additional","affiliation":[{"name":"Laboratorio de Cronobiolog\u00eda Departamento de Ciencia y Tecnolog\u00eda Universidad Nacional de Quilmes\/CONICET Roque S\u00e1enz Pe\u00f1a 352 Bernal Buenos Aires B1876BXD Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-2228","authenticated-orcid":false,"given":"Patricia V.","family":"Agostino","sequence":"additional","affiliation":[{"name":"Laboratorio de Cronobiolog\u00eda Departamento de Ciencia y Tecnolog\u00eda Universidad Nacional de Quilmes\/CONICET Roque S\u00e1enz Pe\u00f1a 352 Bernal Buenos Aires B1876BXD Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.02.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12059"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12728"},{"key":"e_1_2_10_5_1","first-page":"65","volume-title":"Causes and Risks for Autism","author":"Allman M.J.","year":"2009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr210"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-116.2.165"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1163\/22134468-00002035"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2005.05.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/oso\/9780198250357.003.0005","volume-title":"Time and Memory","author":"Boucher J.","year":"2001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000339399.64213.1a"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1764"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12569"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.46867\/ijcp.2015.28.02.06","article-title":"Melatonin modulates interval timing in rats: effect of pinealectomy","volume":"28","author":"Bussi I.L.","year":"2015","journal-title":"Int. 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