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The bed nucleus of stria terminalis (<jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content>) modulates the baroreflex function. However, the local <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in this study, we investigated the involvement of corticotropin\u2010releasing factor (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>) receptors within the <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> of either the selective <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>1<\/jats:sub> receptor antagonist <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>376395 (5\u00a0nmol\/100\u00a0nL) or the selective <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>2<\/jats:sub> receptor antagonist antisauvagine\u201030 (5\u00a0nmol\/100\u00a0nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside. Bilateral microinjection of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>376395 into the <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> decreased the baroreflex bradycardiac response without affecting the reflex tachycardia. Conversely, <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> treatment with antisauvagine\u201030 decreased heart rate response during blood pressure drop without affecting the reflex bradycardia. Overall, these findings provide evidence of an involvement of <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> neurotransmission within the <jats:styled-content style=\"fixed-case\">BNST<\/jats:styled-content> in baroreflex activity. Nevertheless, data indicate that local <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>1<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content><jats:sub>2<\/jats:sub> receptors differently modulate the baroreflex control of heart rate.<\/jats:p>","DOI":"10.1111\/ejn.13622","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T12:12:41Z","timestamp":1497442361000},"page":"1805-1812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>CRF<\/scp><sub>1<\/sub> and <scp>CRF<\/scp><sub>2<\/sub> receptors in the bed nucleus of stria terminalis differently modulate the baroreflex function in unanesthetized rats"],"prefix":"10.1111","volume":"46","author":[{"given":"Leandro A.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology Department of Natural Active Principles and Toxicology School of 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