{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:18:35Z","timestamp":1778681915778,"version":"3.51.4"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA036582"],"award-info":[{"award-number":["R01 DA036582"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug addiction is a chronic disease that is shaped by alterations in neuronal function within the cortical\u2013basal ganglia\u2010thalamic circuit. However, our understanding of how this circuit regulates drug\u2010seeking remains incomplete, and relapse rates remain high. The midline thalamic nuclei are an integral component of the cortical\u2013basal ganglia\u2010thalamic circuit and are poised to mediate addiction behaviors, including relapse. It is surprising that little research has examined the contribution of midline thalamic nuclei and their efferent projections in relapse. To address this, we expressed inhibitory, G<jats:sub>i\/o<\/jats:sub>\u2010coupled <jats:styled-content style=\"fixed-case\">DREADD<\/jats:styled-content>s (Designer Receptors Exclusively Activated by Designer Drugs) in a subset of the midline thalamic nuclei or in midline thalamic nuclei neurons projecting to either the nucleus accumbens or the amygdala. We examined the effect of transiently decreasing activity of these neuronal populations on cue\u2010induced and cocaine\u2010primed reinstatement of cocaine\u2010seeking. Reducing activity of midline thalamic nuclei neurons attenuated both cue\u2010induced and cocaine\u2010primed reinstatement, but had no effect on cue\u2010induced reinstatement of sucrose\u2010seeking or locomotor activity. Interestingly, attenuating activity of efferent projections from the anterior portion of midline thalamic nuclei to the nucleus accumbens blocked cocaine\u2010primed reinstatement but enhanced cue\u2010induced reinstatement. Decreasing activity of efferent projections from either the posterior midline thalamic nuclei to the nucleus accumbens or the midline thalamic nuclei to amygdala had no effect. These results reveal a novel contribution of subsets of midline thalamic nuclei neurons in drug\u2010seeking behaviors and suggest that modulation of midline thalamic nuclei activity may be a promising therapeutic target for preventing relapse.<\/jats:p>","DOI":"10.1111\/ejn.13631","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T05:46:43Z","timestamp":1498801603000},"page":"1850-1862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chemogenetic inhibition reveals midline thalamic nuclei and thalamo\u2010accumbens projections mediate cocaine\u2010seeking in rats"],"prefix":"10.1111","volume":"46","author":[{"given":"Amanda M.","family":"Wunsch","sequence":"first","affiliation":[{"name":"Center for Integrative Brain Research Seattle Children's Research Institute 1900 9th Ave Seattle WA 98101 USA"},{"name":"Graduate Program in Neuroscience University of Washington Seattle WA 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