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Abnormal fronto\u2010parietal functional connectivity has been widely reported in the literature; this may be underpinned by disrupted microstructural organisation of white matter. The superior longitudinal fasciculus (<jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content>) is a major fronto\u2010parietal white matter tract, the structure of which has been little studied in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. The fronto\u2010parietal projections of this tract (<jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content> I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) are thought to play an important role in a number of cognitive functions including attention and visuospatial processing. To date, the isolation of the fronto\u2010parietal branches of the <jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content> has been hampered by limitations of traditional tractography approaches. Constrained spherical deconvolution (<jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content>)\u2010based tractography is an advanced approach that allows valid isolation of the fronto\u2010parietal branches of the <jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content>. Diffusion <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data were acquired from 45 participants with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and 45 age\u2010 and <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>\u2010matched controls. The <jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content> I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> branches were isolated using <jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content>\u2010based tractography in Explore<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>. Significantly greater fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) was observed in the right <jats:styled-content style=\"fixed-case\">SLF II<\/jats:styled-content> relative to controls. The <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group also showed greater linear diffusion coefficient in the left <jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content> I and the right <jats:styled-content style=\"fixed-case\">SLF II<\/jats:styled-content>. In the <jats:styled-content style=\"fixed-case\">SLF II<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group had significantly greater right lateralisation of <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> in comparison with the control group. The clinical and functional implications of increased <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> in white matter are poorly understood; however, it is possible that this increased white matter organisation in the <jats:styled-content style=\"fixed-case\">SLF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> may contribute to relative processing advantages in the condition.<\/jats:p>","DOI":"10.1111\/ejn.13655","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T11:22:48Z","timestamp":1500981768000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Abnormal fronto\u2010parietal white matter organisation in the superior longitudinal fasciculus branches in autism spectrum disorders"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-4378","authenticated-orcid":false,"given":"Jacqueline","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine Trinity College Dublin Dublin Ireland"},{"name":"Trinity College Institute of Neuroscience Trinity College Dublin Lloyd Building Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Leemans","sequence":"additional","affiliation":[{"name":"Image Sciences Institute University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience Trinity College Dublin Lloyd Building Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"O'Hanlon","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience Trinity College Dublin Lloyd Building Dublin Ireland"},{"name":"Department of Psychiatry Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Trinity College Dublin Dublin Ireland"},{"name":"Linndara Child and Adolescent Mental Health Service Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Trinity College Dublin Dublin Ireland"},{"name":"Linndara Child and Adolescent Mental Health Service Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1105"},{"key":"e_1_2_10_4_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u2010V","author":"APA","year":"2013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp282"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.047"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.066"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3340-04.2004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.060"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.07.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-148"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.110197"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl244"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq108"},{"key":"e_1_2_10_17_1","first-page":"1532","article-title":"Asymmetry and structure of the fronto\u2010parietal networks underlie visuomotor processing in humans","volume":"27","author":"Budisavljevic S.","year":"2017","journal-title":"Cereb. 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